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Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas.
2004 SEP 18 - (NewsRx.com & NewsRx.net) -- Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas.
"Three series of pyridinium cationic lipids useful as nonviral gene delivery agents were prepared by reaction of pyrylium salts with aminodiols, followed by acylation with fatty acyl chlorides. On the basis of this set of compounds, we undertook a comprehensive structure-activity relationship study at the level of the linker, hydrophobic anchor, and counterion in order to identify the structural elements that generate the highest transfection efficiency for this new type of cationic lipid," researchers in the United States report.
"The results revealed that when formulated with cholesterol at a 1:1 molar ratio, the 1-(1,3-dimyristoyloxyprop-2-yl)-2,4,6-trimethylpyridinium, under the form of hexafluorophosphate (5AMyr) or chloride (5DMyr), was able to transfect NCl-H23 lung carcinoma with efficiencies surpassing classic DOTAP-based formulations and with lower cytotoxicity," ...
- GENEMEDICINE Receives Broad Patent Covering the Use of Cationic Lipids for Gene...
- Press release article from: Business Wire October 15, 1997 700+ words
...common routes of administration. Cationic lipids are widely used in non-viral gene...have demonstrated the capability of cationic lipids to deliver effective levels of genes...University discovered this utility of cationic lipids which forms the basis of the patent...
- Cationic Lipids Enhance Adenoviral Infection.
- Newspaper article from: Gene Therapy Weekly July 12, 1999 700+ words
...PUBLISHER www.newsfile.com) -- Cationic lipids and polymers enhance adenovirus...infection in cultured myotubes ("Cationic Lipids and Polymers are Able to Enhance Adenoviral...by complexing virus particles with cationic lipids or cationic polymers," wrote Dodds...
- Cationic lipids may soon be used for DNA transfection in humans.
- Newspaper article from: Cancer Weekly August 19, 2003 700+ words
...Advances in transfection using cationic lipids for DNA delivery still have some problems...Among other strategies, the use of cationic lipids as autoassembling vehicles for non...study in Current Medicinal Chemistry (Cationic lipids for transfection. Curr Med Chem...
- Cationic Lipids Enhance Cytokine and Cell Influx Levels in the Lung Following...
- Newspaper article from: Immunotherapy Weekly June 8, 1998 700+ words
...Nochumson, S.; Petrak, K.L. "Cationic Lipids Enhance Cytokine and Cell Influx Levels...enhanced by the lipid formulation; 2) cationic lipids by themselves do not induce IL-12...TNF-alpha is rapidly induced by cationic lipids and plasmid/lipid complex, but...
- Gadolinium cationic lipids are new tools for transfection.
- Newspaper article from: Gene Therapy Weekly March 20, 2003 700+ words
...amp; NewsRx.net) -- Gadolinium cationic lipids are new tools for transfection. According...France, "gadolinium-chelating cationic lipids have been synthesized to obtain lipoplexes...synthesis, and evaluation of gadolinium cationic lipids as tools for biodistribution studies...
- Polycations/Cationic Lipids Enhance Adenovirus Transduction.
- Newspaper article from: Gene Therapy Weekly November 8, 1999 700+ words
...NewsRx.com) -- Polycations and cationic lipids enhance adenovirus-mediated transduction...Cancer Gene Therapy ("Polycations and Cationic Lipids Enhance Adenovirus Transduction and...adenovirus preparations with polycations, cationic lipids, and CaCl[2] prior to transduction...
- New cationic lipids with photocleavable spacers enhance transfection efficiency.
- Newspaper article from: Gene Therapy Weekly July 17, 2003 700+ words
...com & NewsRx.net) -- New cationic lipids with photocleavable spacers enhance...published research from Japan, "new cationic lipids having an o-nitrobenzyl moiety as...transfection efficiency using novel cationic lipids having a photocleavable spacer. Bioconjugate...
- Polycations/Cationic Lipids Enhance Adenovirus Transduction.(Statistical Data...
- Newspaper article from: Cancer Weekly November 8, 1999 700+ words
...NewsRx.com) -- Polycations and cationic lipids enhance adenovirus-mediated transduction...Cancer Gene Therapy ("Polycations and Cationic Lipids Enhance Adenovirus Transduction and...adenovirus preparations with polycations, cationic lipids, and CaCl[2] prior to transduction...