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Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas.

Obesity, Fitness & Wellness Week

| September 18, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 SEP 18 - (NewsRx.com & NewsRx.net) -- Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas.

"Three series of pyridinium cationic lipids useful as nonviral gene delivery agents were prepared by reaction of pyrylium salts with aminodiols, followed by acylation with fatty acyl chlorides. On the basis of this set of compounds, we undertook a comprehensive structure-activity relationship study at the level of the linker, hydrophobic anchor, and counterion in order to identify the structural elements that generate the highest transfection efficiency for this new type of cationic lipid," researchers in the United States report.

"The results revealed that when formulated with cholesterol at a 1:1 molar ratio, the 1-(1,3-dimyristoyloxyprop-2-yl)-2,4,6-trimethylpyridinium, under the form of hexafluorophosphate (5AMyr) or chloride (5DMyr), was able to transfect NCl-H23 lung carcinoma with efficiencies surpassing classic DOTAP-based formulations and with lower cytotoxicity," ...

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