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Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas.
2004 SEP 18 - (NewsRx.com & NewsRx.net) -- Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas.
"Three series of pyridinium cationic lipids useful as nonviral gene delivery agents were prepared by reaction of pyrylium salts with aminodiols, followed by acylation with fatty acyl chlorides. On the basis of this set of compounds, we undertook a comprehensive structure-activity relationship study at the level of the linker, hydrophobic anchor, and counterion in order to identify the structural elements that generate the highest transfection efficiency for this new type of cationic lipid," researchers in the United States report.
"The results revealed that when formulated with cholesterol at a 1:1 molar ratio, the 1-(1,3-dimyristoyloxyprop-2-yl)-2,4,6-trimethylpyridinium, under the form of hexafluorophosphate (5AMyr) or chloride (5DMyr), was able to transfect NCl-H23 lung carcinoma with efficiencies surpassing classic DOTAP-based formulations and with lower cytotoxicity," ...
- GENEMEDICINE Receives Broad Patent Covering the Use of Cationic Lipids for Gene...
- Press release article from: Business Wire October 15, 1997 700+ words
...common routes of administration. Cationic lipids are widely used in non-viral gene...have demonstrated the capability of cationic lipids to deliver effective levels of genes...University discovered this utility of cationic lipids which forms the basis of the patent...
- Gadolinium cationic lipids are new tools for transfection.
- Newspaper article from: Gene Therapy Weekly March 20, 2003 700+ words
...amp; NewsRx.net) -- Gadolinium cationic lipids are new tools for transfection. According...France, "gadolinium-chelating cationic lipids have been synthesized to obtain lipoplexes...synthesis, and evaluation of gadolinium cationic lipids as tools for biodistribution studies...
- Cyclic-head cationic lipids enhance transgene expression in murine lungs.
- Newspaper article from: Obesity, Fitness & Wellness Week July 10, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Cyclic-head cationic lipids enhance transgene expression in murine lungs. "Herein...intravenous transgene expression in mouse lung using cyclic-head cationic lipids. Chem Biol, 2004;11(4):427-437). For additional...
- Megabios Corp. Receives Patents Covering Systemic Gene Delivery Using Cationic...
- Press release article from: PR Newswire November 10, 1998 700+ words
...issued patents relating to aerosolized gene delivery using cationic lipids. "These new patents add to Megabios' already broad patent...DNA plasmids that are combined with positively-charged cationic lipids and/or non-lipid agents to form tight complexes that...
- Megabios Corp. Receives Broad Patent Covering Aerosolized Gene Delivery Using...
- Press release article from: PR Newswire June 4, 1998 700+ words
...aerosolized gene delivery to the lung and airways using cationic lipids. The patent broadly covers methods of delivering aerosolized...delivery of gene-based vaccines via mucosal immunity." Cationic lipids are positively charged lipids which, when combined with...
- Targeted Genetics Announces Issuance of Broad Patent for Lipid-Based Gene...
- Press release article from: PR Newswire August 18, 1998 700+ words
...wide variety of polycations and cationic lipids, and a majority of these possible...demonstrated the utility of using cationic lipids to deliver genes and nucleic acids to cells. Many cationic lipids have been described and characterized...
- Reports on DNA research findings from Northwestern University provide new...
- Newspaper article from: Virus Weekly December 23, 2008 700+ words
...from the United States, "Synthetic cationic lipids can be used as DNA carriers and are...dioleoyl ethyIPC (EDOPC). Noteworthy, cationic lipids with 14:1 hydrocarbon chains have...correlate strongly with the effect of the cationic lipids on the lamellar-to-inverted hexagonal...
- Properties of new multivalent cationic lipid for gene delivery described.
- Newspaper article from: Gene Therapy Weekly January 16, 2003 700+ words
...synthetic scheme can be extended to give cationic lipids of different charge, spacer, or...give indications of why multivalent cationic lipids possess superior transfection properties...minimize the known toxicity effects of cationic lipids," the researchers said. Ewert and...
- Genteric Awarded Key Lipid Patent; Invention Facilitates Therapeutic Gene...
- Press release article from: Business Wire May 4, 2000 700+ words
...of positively charged fat molecules, or cationic lipids. "Although cationic lipids are among the most effective and most widely...contrast, Genteric's newly patented class of cationic lipids demonstrates improved DNA delivery to target...
- ISIS PHARMACEUTICALS OBTAINS LICENSE TO LIPID FORMULATIONS TECHNOLOGY FROM VICAL
- Press release article from: PR Newswire March 11, 1992 700+ words
...the agreement were not disclosed. Cationic lipids are fat-like substances that, when...Vical is a pioneer in the use of cationic lipids for the delivery of genetic material...Our preliminary data indicate that cationic lipids will enhance oligonucleotide entry...
Source: HighBeam Research, Pyridinium cationic lipids surpass the efforts of classic DTOAP-based...