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Johns Hopkins University
A simple technique makes the laboratory test for HIV-p24 antigen five times more sensitive and may expedite clinical trials of experimental AIDS therapies.
A problem with AIDS clinical trials is that there are currently no reliable means of measuring the actual antiviral effect of an experimental drug. Surrogate markers of HIV disease progression, such as CD4+ T-cell counts and [beta.sub.2]-microglobulin levels, only indirectly indicate whether a drug is effective.
Tests for serum HIV-p24 antigen - a direct measure of HIV replication - have been available for some time, but p24 antigenemia can be detected in only about …