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Site-specific cleavage of the transactivation response site of human immunodeficiency virus RNA with a Tat-based chemical nuclease. (Periodical Report)
SOURCE: Proceedings of the National Academy of Sciences, April 15, 1992;89(8):3526-3530.
The creation of a synthetic nuclease that can split off a crucial region of HIV RNA offers a new approach to AIDS therapeutics.
Sumedha D. Jayasena and Brian H. Johnson of SRI International, Menlo Park, California, suggest that the development of RNA-cleaving agents could be a useful means of inactivating viruses. This approach led to the recent development of the catalytic RNA molecules known as ribozymes (Sarver et al., Science, 1990;247:1222-1224).
Jayasena and Johnson, however, take a different approach. They note that HIV replication requires …
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