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Vaginal gene expression after neonatal DES exposure characterized.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Vaginal gene expression after neonatal DES exposure has been characterized.
"Developmental exposure to a synthetic estrogen, diethylstilbestrol (DES), induces carcinogenesis in human and laboratory animals," endocrinologists in Japan explained. "In mice, neonatal DES treatment induces persistent proliferation and keratinization of the vaginal epithelium, even in the absence of the ovaries, resulting in cancerous lesions later in life."
"To understand the mechanisms underlying this persistent cell proliferation and differentiation," S. Miyagawa and colleagues at the Okazaki National Research Institute "characterized the gene expression patterns in the neonatally DES-exposed mouse vagina using DNA microarray and real-time quantitative RT-PCR."
"We found that genes related to cellular signaling, which are candidates for mediating the persistent proliferation and differentiation, were altered, and genes related to the immune system were decreased in the neonatally DES-exposed mouse vagina," the collaborators said. "We also noted high expression of interleukin-1 (IL-1)-related genes accompanied by phosphorylation of JNK1."
"In addition, expression of IGF-1 and its binding proteins was modulated and led to phosphorylation of IGF-1 receptor and Akt, which is one of the ...
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