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Low doses of mifepristone or levonorgestrel appear to prevent or delay LH surge.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Single low-dose mifepristone or levonorgestrel appears to work as an emergency contraceptive by preventing or delaying the surge in luteinizing hormone, thus inhibiting or delaying ovulation, according to research from Sweden.
"An emergency contraceptive method is used after coitus but before pregnancy occurs. The use of emergency contraception is largely under-utilized worldwide. One of the main barriers to widespread use is concern about the mechanism of action," said K. Gemzell-Danielsson and colleagues, Karolinska Hospital Institute.
"Recently, treatment with either 10 mg mifepristone or 1.5 mg levonorgestrel has emerged as the most effective hormonal method for emergency contraception with very low side effects. However, the knowledge of the mechanism of action of mifepristone and levonorgestrel in humans, when used for contraceptive purposes and especially for emergency contraception, remains incomplete," the researchers said.
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