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Superoxide dismutase mimetic may be cardioprotective alternative to estrogen.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- The superoxide dismutase (SOD) mimetic EUK-8 may serve as an alternative to estrogen in protecting older women from heart attack, say University of Alberta researchers.
"Aging and estrogen deficiency increase the risk for developing cardiovascular disease (CVD). Oxidative stress has also been implicated in the pathophysiology of CVD and in ischemia-reperfusion (I/R) injury. We tested the hypothesis that chronic in vivo estrogen treatment or superoxide inhibition with the SOD mimetic EUK-8 improves cardiac functional recovery after I/R in the aged female rat," said Y. Xu and colleagues.
"Sprague-Dawley rats (12-14 months) were used as follows: intact (n=6), ovariectomized + placebo (OVX, n=6), OVX + EUK-8 (EUK-8, 3 mg/kg, n=6), and OVX + estrogen (1.5 mg/pellet, 60 days release, n=6). Perfused isolated hearts were subjected to global ischemia (25 minutes) followed by reperfusion (40 minutes).
"Functional recovery after I/R and myocardial protein expression of NADPH oxidase [p22, p67, and gp91(phox)], inducible nitric oxide synthase (NOS), endothelial NOS, and SOD1, as well as nitrotyrosine levels (as a marker for peroxynitrite) were assessed," according to the report.
The researchers found that "[c]ompared with [the OVX rats], EUK-8 and estrogen markedly improved functional recovery after I/R, which was associated with a decrease in NADPH oxidase expression and nitrotyrosine staining.
"However, estrogen ...
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Source: HighBeam Research, Superoxide dismutase mimetic may be cardioprotective alternative to...