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Isoflavones in nursing rats' diet alter PR regulation by estrogen.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Rat pups exposed to isoflavones via suckling were found to have increased levels of progesterone receptor (PR) in the uterine glandular epithelium as they reached maturity.
What long-term repercussions for reproductive health this modification of PR expression may have is unknown.
"In utero and lactational exposure to estrogenic agents has been shown to influence morphological and functional development of reproductive tissues. Thus, consumption of dietary phytoestrogens, such as isoflavones, during pregnancy and lactation could influence important periods of development, when the fetus and neonate are more sensitive to estrogen exposure," hypothesized C.L. Hughes and colleagues, Quintiles Inc., Research Triangle Park, North Carolina.
They examined "reproductive outcomes after developmental exposure to isoflavones . . . in Long-Evans rats maternally exposed to isoflavones via a commercial soy beverage or as the isolated isoflavone, genistein."
"Most reproductive endpoints examined at birth, weaning, and 2 months of age were not significantly modified in pups of either sex after lactational exposure to soy milk (provided to the dams in place of drinking water) from birth until weaning. However, soy milk exposure induced a significant increase in progesterone receptor (PR) in the uterine glandular epithelium of the 2-month-old pups," Hughes and team reported.
"In pregnant dams treated with genistein (GEN; 15 mg/kg body weight) by gavage, from Gestational Day 14 through weaning, PR expression in the uterine glandular epithelium from 2-month-old GEN-treated females (postexposure) was also significantly increased," they said.
Rats exposed to diethylstilbesterol (DES) also exhibited increased uterine PR expression only in the glandular but not ...
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