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Smoking, number of sex partners are epigenetic risk factors in NE Thailand.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Smoking and number of sex partners have been identified as epigenetic risk factors in Northeastern Thailand for developing cervical cancer.
"Relationships between cervical cancer and risk factors were investigated in Northeastern Thailand. Cases (n=90) with squamous cell cervical cancer (SCCA) and age matched healthy controls (n=100) were recruited. The p53 codon 72 polymorphism, proline and arginine allele, was studied by the polymerase chain reaction-restriction fragment length polymorphism," said W. Settheethamishida and colleagues, Khon Kaen University.
The researchers found no significant difference between the two groups in terms of allele and the genotype distribution.
However, they reported, "Significant difference was observed in the number of sexual partners (p
When Settheethamishida and associates adjusted for age and p53 genotype, their analysis still showed that number of sex partners was statistically significant (p=.017).
Additionally, "The partners' smoking increased the risk to develop SCCA. Increased odds ratios were observed when the partner had smoking history both at present (3.31; p
The researchers concluded that "[t]he p53 polymorphism itself may not be a risk factor for cervical ...
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Source: HighBeam Research, Smoking, number of sex partners are epigenetic risk factors in NE...