AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Mechanism described by which POU transcription factor represses growth in vitro.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Results of a study from Japan suggest the POU transcription factor human Skn-1a "represses growth of the cervical cancer cells through the partial resumption of the differentiation pathway followed by slow suppression of cell replication and apoptosis."
"The POU transcription factor human Skn-1a (hSkn-1a) specifically promotes the proliferation of keratinocytes and enhances their differentiation," said Y. Enomoto and colleagues at Japan's National Institute of Infectious Diseases.
The research team "examined the effects of hSkn-1a on cervical cancer cell lines of epithelial origin, in which the differentiation program is interrupted."
"From HeLa/Tet-On, a clone that can be induced to make hSkn-1a by doxycycline (HeLa/hSkn-1a) was prepared and characterized. Shortly after the induction, the cells expressed cytokeratin 10 (K10), a major marker protein in differentiating keratinocytes," the scientists said.
They reported, "While maintained for several days in the presence of doxycycline, the HeLa/hSkn-1a cells showed a slightly prolonged time of population doubling, the occasional appearance of cells with lowered DNA synthesis, and a low level of apoptotic DNA fragmentation.
"In SiHa and HeLa S3 ...
- Fingering the right genes in development. (transcription factor variations)...
- Magazine article from: Science News Ezzell, Carol September 26, 1992 700+ words
...researchers have predicted that each transcription factor controls a separate platoon of related...indicates that a given type of transcription factor can vary during the development...possess a different form of the transcription factor that regulates this gene. Males...
- Transcription Factor Decoys.(Brief Article)
- Magazine article from: The Scientist Flanagan, Anita M. September 17, 2001 700+ words
...tools for gene regulation studies Transcription factor oligodeoxynucleotide (ODN) decoys...can negate the ability of the transcription factor to regulate gene expression. The...standard consensus regions are from transcription factor databases available on the Internet...
- Microarray detection of transcription factor-binding motifs enhanced.
- Newspaper article from: Genomics & Genetics Weekly July 23, 2004 700+ words
...enhances microarray detection of transcription factor-binding elements "As a powerful...a simple approach to detect the transcription factor-binding motif using microarray...from a mutant in which the relevant transcription factor is deleted." "A core part of...
- Clustering enhances microarray detection of transcription factor-binding motifs.
- Newspaper article from: Proteomics Weekly July 12, 2004 700+ words
...enhances microarray detection of transcription factor-binding elements. "As a powerful...a simple approach to detect the transcription factor-binding motif using microarray...from a mutant in which the relevant transcription factor is deleted." "A core part of...
- Thyroid transcription factor 1 immunohistochemistry as an intraoperative...
- Magazine article from: Archives of Pathology & Laboratory Medicine Butcher, David N. Goldstraw, Peter Ladas, George Dusmet, Michael E. Sheppard, Mary N. Nicholson, Andrew G. April 1, 2007 700+ words
...immunohistochemistry for thyroid transcription factor 1 at the time of intraoperative...looked for expression of thyroid transcription factor 1, using the EnVision system with...cases were positive for thyroid transcription factor 1, which was confirmed on subsequent...
- Forkhead box transcription factor is essential to liver cancer formation.
- Newspaper article from: Cancer Weekly June 29, 2004 700+ words
...NewsRx.net) -- Forkhead box transcription factor is essential to liver cancer formation...Fox) m1b (Foxm1b or Foxm1) transcription factor is essential for the development...phosphatase. We showed that the Foxm1b transcription factor is a novel inhibitory target of...
- Marligen Announces New Transcription Factor Assays; New Tool Helps Scientists...
- Press release article from: Business Wire May 12, 2004 700+ words
...simultaneously, the Marligen Multiplexed Transcription Factor System allows scientists to analyze...controlling their costs." "These Transcription Factor Assays also have the potential of...to add more capabilities to our Transcription Factor Assays so that many dozens of proteins...
- Transcription factor cCP2 controls gene expression in embryonic stem cells.
- Newspaper article from: Biotech Week July 7, 2004 700+ words
...com & NewsRx.net) -- Transcription factor cCP2 controls gene expression in...described response element for the transcription factor CP2 and we show by supershift experiments...nuclear factor belonging to the CP2 transcription factor family that is crucial for the activation...
- Transcription factor activation following exposure of an intact lung...
- Magazine article from: Environmental Health Perspectives Samet, James M. Silbajoris, Robert Huang, Tony Jaspers, Ilona October 1, 2002 700+ words
...NF[kappa]B), activating transcription factor-2 (ATF-2), c-Jun, and...of immunohistochemistry to detect transcription factor activation in vivo and demonstrate...protein-1 (AP-I), activating transcription factor-2 (ATF-2), and cAMP response...
- Anesiva and Transcription Factor Therapeutics, Inc. Announce Licensing...
- Press release article from: PR Newswire June 5, 2008 700+ words
...candidate Avrina(TM), to Transcription Factor Therapeutics, Inc. (TFT). NF-kB Transcription Factor Decoy inhibits NF-kappa B...focus on anti-inflammatory transcription factor decoys, we believe that TFT...
Source: HighBeam Research, Mechanism described by which POU transcription factor represses...