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HPV DNA subtype is prognostic factor in early stage disease.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Gynecologic oncologists in Sweden have determined that the subtype of human papillomavirus (HPV) present in cervical cancer tumors is a prognostic factor in early-stage cervical cancer.
M. Graflund and colleagues, Orebro University Hospital, examined "the relation between the expression of p53, bcl-2, p21(WAF1), MIB-1, HER-2/neu, DNA ploidy, and HPV16 or 18 infections with clinical parameters."
"HPV-DNA was evaluated in 171 early cervical carcinomas treated from 1965 to 1990 and detected by polymerase chain reaction on paraffin specimens obtained before therapy was started," the researchers said.
They found HPV DNA in 86 of 110 tumors (78%). By subtype, HPV16 was detected 62 of the 110 tumors (56%), HPV18 in 9 tumors (8%), and HPV35 in 23 tumors (21%).
Graflund and coworkers reported, "Patients with HPV16 or 18 were significantly (p=.011) younger than patients with tumors not containing these two HPV subtypes. Lymph node metastases were seen more frequently (p=.047) in tumors expressing HPV16 or 18. Tumor size was associated with the HPV-type.
"The frequency of DNA aneuploidy was lower in high-risk HPV tumors than in tumors with other HPV subtypes (p=.014). MIB-1 expression was highly significantly (p=.00007) associated with presence of HPV 16 or 18," they continued.
Their analysis also showed a ...
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Source: HighBeam Research, HPV DNA subtype is prognostic factor in early stage disease.