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Systemic inflammation unrelated to pathogens associated with syndrome X.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Systemic inflammation seen in women with cardiac syndrome X is unrelated to infectious pathogens associated with the condition, report cardiologists in Italy.
"Inflammation plays a key role in coronary artery disease (CAD), but whether it is involved in the pathogenesis of syndrome X (SX) is not known. Thus, we assessed the presence of systemic inflammation in patients with SX and its possible relation to infections from Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus, and Epstein-Barr virus," said G.A. Lanza and colleagues, University Cattolica S. Cuore, in Rome.
They measured plasma levels of high-sensitivity C-reactive protein and interleukin-1 receptor antagonist in 55 women with SX (mean age, 57 [+ or -] 8; 27 women), 49 with stable angina and obstructive CAD (mean age, 56 [+ or -] 8; 24 women), and 60 healthy controls (mean age, 57 [+ or -] 11; 24 women).
"Infection from H. pylori, C. pneumoniae, cytomegalovirus, and Epstein-Barr virus was assessed in 43 patients with SX, 40 patients with CAD, and in 39 controls," according to the study.
Lanza and associates found that serum levels of C-reactive protein were lower in women with SX than those with CAD (4.06 [+ or -] 6.8 vs. 5.99 [+ or -] 7.8 mg/L, p=.013) but higher than in the control group (1.75 [+ or -] 1.98 mg/L; p=.008).
They reported, "Plasma levels of interleukin-1 receptor antagonist were higher in patients with CAD (570 [+ or -] 738 pg/ml) and patients with SX (494 [+ or -] 677 pg/ml) than in controls (254 ...
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