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Menopausal variations in cholesterol influenced by APOE genotype.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Menopausal variations in cholesterol are influenced by apolipoprotein E genotype, researchers report.
"During menopause, a sharp increase in cholesterol concentration occurs with an unexplained wide variation in change. Possibly, this is attributable to genetic variation," wrote A.E. Hak and colleagues, Erasmus MC.
They explored this by "prospectively [studying] the effect of the apolipoprotein E (APOE) genotype on the change in cholesterol level with menopause among 116 Dutch women."
"Women with the APOE3E3 genotype were regarded as the reference category and changes were adjusted for age at baseline, years of follow-up, years since menopause, and body mass index. At baseline, the women were on average 50.4 years," the researchers said.
They reported, "After 5.9 years of follow-up, the women were on average 4.3 years (SD 1.5 years) postmenopausal. The mean increase in cholesterol with menopause in women with the APOE3E3 genotype was 0.67 mmol/L (95% CI, 0.61-0.72 mmol/L). In women with the APOE2E3 genotype the increase in cholesterol was 0.44 mmol/L (Cl, 0.32-0.56 mmol/L). The increase in cholesterol in women with the APOE3E4 genotype did not differ from ...
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- Different genotypes affect long-term outcome of chronic hepatitis B.
- Newspaper article from: Hepatitis Weekly January 27, 2003 700+ words
...hepatitis B virus can expect viral genotype to play a role in their progression...hepatitis B virus (HBV) genotype," researchers said. "The...B infected with different genotypes of HBV were compared," stated...reported that "the prevalence of genotype A, D, and F was 52%, 35...
- HCV Genotype Doesn't Impact Outcome in Renal Patients.
- Newspaper article from: Hepatitis Weekly Boyles, Salynn August 23, 1999 700+ words
...hepatitis C virus (HCV) genotypes and multiple genotype infections. However...number of infecting HCV genotypes on survival among ESRD...infected with a single HCV genotype, 16 patients (9 percent) with two genotypes, and two patients...
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- Newspaper article from: Biotech Business Week February 2, 2004 700+ words
...insertion homozygous (II) genotype, or the 490-bp insertion...deletion heterozygous (ID) genotype." "The achieved change...analyzed for association with genotypes at the ACE gene focus," according to the report. "The DD genotype was observed in 132 patients...
