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Tissue inhibitors of MMPs increased in women with capsular contracture.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- According to a study by plastic surgeons, tissue inhibitors of metalloproteinases are increased in women with capsular contracture after insertion of breast implants.
"In various fibrotic diseases, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role. In our study, serum concentrations of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined by enzyme-linked immunosorbent assay in 17 female patients with Baker grade II (n=9), III (n=7), and IV (n=1) capsular contracture after bilateral cosmetic mamma augmentation with Trilucent implants (AEI, Inc., Caversham, U.K.)," wrote D. Uhich and colleagues, Aachen University Hospital, Germany.
"Samples of capsular tissue for standard histology and immunohistochemistry were obtained from all patients. Sera from 20 female patients who had plastic surgery for reduction mammaplasty were used as the control group. The aminoterminal propeptide of procollagen type III (PIIINP) and hyaluronan were analyzed as markers for fibrogenesis in both groups, too," the team wrote in their report.
The women with capsular contracture had "significantly higher concentrations of TIMP-I and TIMP-2 in their sera than did the control group (p
"The concentration of MMP-2 was significantly higher in the sera of patients with capsule fibrosis, whereas there were no significant differences in MMP-1, MMP-9, and PIIINP serum concentrations. Patients with capsule fibrosis had a significantly lower MMP-to-TIMP ratio (1.1 [+ or -] 0.4, p
"The hyaluronan serum concentration of patients with capsular contracture was significantly higher (p
Histology revealed "chronic inflammatory reaction in the capsules around the breast implants and refracting material within the substance. Immunohistochemically, TIMP-1 and TIMP-2 showed an intensive accumulation, and MMP-2 showed a local reaction. PIIINP could be detected, too, whereas there was no staining for MMP-1 and MMP-9," wrote Uhich's group.
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Source: HighBeam Research, Tissue inhibitors of MMPs increased in women with capsular...