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Tamoxifen and soluble tumor-associated antigens suppress breast cancer.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Treatment with tamoxifen and soluble tumor-associated antigens stimulate T- and B-lymphocyte responses to breast cancer tumors.
According to recent research published in the journal Oncology Reports, "We analyzed the role of T- and B-lymphocytes in the antitumor effects of the anticancer drug tamoxifen and soluble tumor-associated antigens (sTAA) on rat mammary carcinogenesis. Studies were performed on the spleen from the following groups of mammary tumor-bearing rats. Rats in group 1 were not exposed to DMBA and served as age-related controls."
"Rats in other groups were exposed to DMBA and received different types of treatment: rats in group 2 received no additional treatment and served as carcinogen-related controls; rats in group 3 were treated with the commercial hormone-dependent anticancer drug tamoxifen by weekly subcutaneous (s.c.) injections of 10 mg dissolved in 0.5 mL distilled water per rat; rats in group 4 were vaccinated s.c. weekly with a preparation of sTAA (50 microliter/rat) dissolved in 0.5 mL of phosphate-buffered saline; rats in group 5 were treated with tamoxifen and were also vaccinated with a preparation of sTAA," reported H. Benhur and colleagues at Hebrew University of Jerusalem.
"Different zones of the spleen were measured and their T- and B-cell contents were analyzed immunohistochemically," stated the researchers. "The treatment with tamoxifen significantly increased the total number of lymphocytes in the follicles, PALS (periarterial lymph sheath), and red pulp relative to all other groups. The combined treatment with tamoxifen and sTAA increased the areas of white pulp, the PALS, and ...
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Source: HighBeam Research, Tamoxifen and soluble tumor-associated antigens suppress breast...