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HER2 expression in metastases determined.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Expression of the HER2 oncogene product has been characterized in metastatic breast cancer.
Oncologists in Sweden conducted a study "to evaluate whether the HER2 expression in breast cancer is retained in metastases."
"The HER2 expression in primary tumors and the corresponding lymph node metastases were evaluated in parallel samples from 47 patients," explained J. Carlsson and coauthors at the University of Uppsala Hospital. "The HercepTest was used for immunohistochemical analyses of HER2 overexpression in all cases," while "CISH/FISH was used for analysis of gene amplification in some cases."
"HER2 overexpression (HER2 scores 2+ or 3+) was found in 55% of both the primary tumors and of the lymph node metastases," Carlsson and collaborators said. "There were only small changes in the HER2 scores; six from 1+ to 0 and one from 3+ to 2+ when the metastases were compared to the corresponding primary tumors. However, there were no cases with drastic changes in HER2 expression between the primary tumors and the corresponding lymph node metastases."
"The literature was reviewed for similar investigations," and the results indicated that "breast cancer lymph node metastases generally overexpress HER2 to the same extent as the ...
- Stringent clinical criteria differentiate second primary tumors from metastases.
- Newspaper article from: Cancer Vaccine Week September 29, 2003 700+ words
...clinical criteria differentiate second primary tumors from metastases. According to recent...represent contralateral metastases or new primary tumors. "The presence of carcinoma in situ...five were concluded to be distinct primary tumors using clinical criteria; some were...
- The Relation of Second Primary Tumors to Index Tumors.
- Newspaper article from: Cancer Weekly July 25, 2000 700+ words
...examine the incidence, localization, and extent of second primary tumors occurring in patients with primary laryngeal carcinoma...grade of differentiation between the index tumors and second primary tumors. E.D.A.V.E. Esposito and colleagues of Naples...
- Herpes simplex virus-1 treatment of primary tumors reduces metastatic cancer.
- Newspaper article from: Gene Therapy Weekly November 27, 2003 700+ words
...NewsRx.net) -- Herpes simplex virus-1 treatment of primary tumors reduces metastatic cancer. "The HSV-1 1716 mutant virus...published their study in Molecular Therapy (HSV-1 therapy of primary tumors reduces the number of metastases in an immune-competent...
- Some stomal recurrences after total laryngectomy may be second primary tumors.
- Newspaper article from: Medical Devices & Surgical Technology Week September 21, 2003 700+ words
...stomal recurrences after total laryngectomy may be second primary tumors. According to published research from Italy, "The aim...the hypothesis that a subset of SRs after TL may be second primary tumors, genetically unrelated to the primary laryngeal lesion...
- Outcome of MFH is associated with the genetic profiles of the primary tumors.
- Newspaper article from: Biotech Week October 15, 2003 700+ words
...histiocytomas (MFH) is associated with the genetic profiles of the primary tumors. "In this study, a panel of 39 primary malignant fibrous...outcome of MFH is associated with the genetic profiles of the primary tumors. Importantly, a subgroup of MFHs characterized by a low...
- Development and Characterization of a Cytokine-Secreting Pancreatic...
- Newspaper article from: Vaccine Weekly July 13, 1998 700+ words
...Cytokine-Secreting Pancreatic Adenocarcinoma Vaccine From Primary Tumors for Use in Clinical Trials." Cancer Journal from Scientific...method for the routine generation of in vitro cell lines from primary tumors of the pancreas. This method overcomes the common problem...
- Four primary tumors of lung, bladder, prostate, and breast in a male...
- Magazine article from: Southern Medical Journal Otrock, Zaher K. Mahfouz, Rami A.R. Salem, Ziad M. September 1, 2005 700+ words
...to be negative for p53 over-expression. To our knowledge, this is the first documented case with this combination of primary tumors. The tumors included an adenosquamous cell carcinoma of the lung, transitional cell carcinoma of the urinary bladder...
- Radiation therapy can cause second primary tumors.
- Newspaper article from: Clinical Oncology Week May 10, 2004 700+ words
...of increasing importance. Within the thorax, radiation therapy is more commonly the cause of treatment-related second primary tumors than is chemotherapy," wrote L.B. Zablotska and colleagues, Columbia University, Mailman School of Public Health...
