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HER-2 amplification can be acquired with breast cancer progression.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Contrary to conventional wisdom, HER-2 gene amplification can be acquired during breast cancer progression.
"Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor and metastases," oncologists in the United States explained. "Therefore, patients with HER-2-negative primary tumors rarely will receive anti-Her-2 antibody (trastuzumab, Herceptin) therapy."
In a study conducted by S.D. Meng and colleagues at the University of Texas, a "very sensitive blood test was used to capture circulating tumor cells (CTCs) and evaluate their HER-2 gene status by fluorescence in situ hybridization."
"The HER-2 status of the primary tumor and corresponding CTCs in 31 patients showed 97% agreement, with no false positives," the collaborators found. "In 10 patients with HER-2-positive tumors, the HER-2/chromosome enumerator probe 17 ratio in each tumor was about twice that of the corresponding CTCs (mean 6.64[+ or -]2.72 vs. 2.8[+ or -]0.6). Hence, the ratio of the CTCs is a reliable surrogate marker for the expected high ratio in the primary tumor."
"Her-2 protein expression of 10 CTCs was sufficient to make a definitive diagnosis of the HER-2 gene status of the whole population of CTCs in 19 patients with recurrent breast cancer," ...
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Source: HighBeam Research, HER-2 amplification can be acquired with breast cancer progression.