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Changes in CD38/cADPR pathway may affect uterine motility and onset of labor.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Hormone-induced changes in the CD38/cADPR pathway may affect uterine motility and onset of labor, suggest University of Minnesota researchers.
"Cyclic ADP-ribose (cADPR), synthesized by CD38, regulates intracellular calcium in uterine smooth muscle. CD38 is a transmembrane protein that has both ADP-ribosyl cyclase and cADPR hydrolase enzyme activities involved in cADPR metabolism. CD38 expression and its enzyme activities in uterine smooth muscle are regulated by estrogen," explained S. Dogan and colleagues.
They "examined CD38 expression, its enzyme activities, and cADPR levels in myometrium obtained from rats at 14-17 days of gestation (preterm) and at parturition (term)."
Uterine tissue from term rats had higher CD38 expression, ADP-ribosyl cyclase activity, and cADPR levels than that of preterm rats, Dogan and team found; cADPR hydrolase did not change between groups.
"In an effort to address whether changes in estrogen: progesterone ratio that occur during pregnancy account for the observed effects on CD38 expression and function, we determined the effect of different doses of progesterone in the presence of estrogen on CD38 expression and its enzyme activities in uterine smooth muscle obtained from ovariectomized rats," Dogan and colleagues wrote.
They reported that CD38 protein expression and ADP-ribosyl ...
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Source: HighBeam Research, Changes in CD38/cADPR pathway may affect uterine motility and onset...