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Circulating leptin associated with oxidized LDL in postmenopausal women.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- Circulating leptin is associated with oxidized low density lipoprotein (LDL) in postmenopausal women, report researchers in Italy.
"Recently, leptin has been suggested as a possible cause of atherosclerotic disease. In the present study, we have investigated in postmenopausal women (n=60; age: 52 [+ or -] 13) the relationship between circulating levels of leptin, oxidized LDL (Ox-LDL), and other biochemical and anthropometric variables of atherosclerotic risk. In addition, we have evaluated soluble thrombomodulin (sTM) as a marker of endothelial damage," wrote E. Porreca and colleagues, University of Chieti.
According to their report, "Ox-LDL showed a positive correlation with leptin circulating levels (r = 0.65, p
"After multivariate regression analysis, leptin was still related to Ox-LDL levels (p=.007)."
Porreca's group also looked at short-term effects of weight loss on certain factors in a subgroup of obese women.
"In obese women who completed the program of weight reduction, leptin changes persisted as a significant predictor of plasma changes in Ox-LDL levels," the researchers reported.
"These findings suggested a novel link between leptin and Ox-LDL, possibly involved ...
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