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Computer model: Short-term HRT improves QOL, decreases life expectancy.
2004 SEP 2 - (NewsRx.com & NewsRx.net) -- A computer-based simulation model indicates that short-term hormone therapy (HT) is associated with increases in quality of life for women with menopausal symptoms, but may shorten life expectancy.
Decisions concerning menopausal hormone therapy are difficult due to the complexity of balancing the risks and benefits of this treatment. HT is an effective treatment for menopausal symptoms and decreases the risks of osteoporosis and colorectal cancer, but it may also increase the risk of coronary heart disease, stroke, blood clots, and breast cancer, study data suggest.
Nananda F. Col, MD, MPP, MPH, of Rhode Island Hospital, Providence, and colleagues investigated which women would benefit from short-term HT by weighing symptom relief against risks of causing disease.
They developed a World Wide Web-based computer model to simulate the effects of short-term HT use (2 years) on life expectancy and quality-adjusted life expectancy (QALE, a measurement of the number of high quality of life years that can be expected over the course of a lifetime) among 50-year-old menopausal women (without hysterectomy). The researchers based their model on findings from the Women's Health Initiative, which reported on some of the risks associated with HT.
Col and team found that among women without any symptoms of menopause, short-term HT was associated with overall losses in life expectancy and QALE of 1 to 3 months, ...
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