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Nasal IgA important for protection from respiratory syncytial virus infection.

Vaccine Weekly

| September 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Nasal IgA antibodies are important for protection from natural respiratory syncytial virus infection in adults.

"Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV) infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large," researchers in the United States report.

"Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection," wrote Edward E. Walsh and Ann R. Falsey at the University of Rochester.

Walsh and Falsey published their study in the ...

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