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Mutated Sabin poliovirus shed after administration of oral poliovirus vaccine.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Sabin poliovirus type 3 containing the nucleotide 472 uracil-to-cytosine point mutation is shed after administration of oral poliovirus vaccine.
According to recent research published in the Journal of Infectious Diseases, "A uracil-to-cytosine point mutation at nucleotide (nt) 472 of Sabin oral poliovirus vaccine (OPV) type 3 is found in conjunction with vaccine-associated paralytic poliomyelitis (VAPP). Direct RNA extraction and mutant analysis by polymerase chain reaction and restriction enzyme cleavage were used to identify this point mutation in clinical samples. A total of 238 stool samples were obtained from 28 healthy infants for 6 weeks after OPV vaccination."
"More than 25% of infants shed OPV3 in the week after vaccination, with a decrease on day 6," reported Claudia V. Martinez and colleagues at Stanford University. "A second wave of OPV3 shedding occurred beginning the second week after vaccination and was maintained through the end of the study period. During the first week after vaccination, the proportion of nt 472 mutants in the shed OPV3 increased from undetectable to almost 100%. During the ...
- Mutated Sabin poliovirus shed after administration of oral poliovirus vaccine.
- Newspaper article from: Immunotherapy Weekly September 1, 2004 700+ words
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- Monovalent live oral poliovirus vaccine reigns supreme
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- Newspaper article from: Biotech Week November 24, 2004 700+ words
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- Lederle supports Institute of Medicine recommendation affirming current oral...
- Press release article from: PR Newswire May 20, 1988 700+ words
...MEDICINE RECOMMENDATION AFFIRMING CURRENT ORAL POLIOVIRUS VACCINE POLICY WAYNE, N.J., May...PRNewswire/ -- Maintaining the current oral poliovirus vaccine schedule, as recommended...Laboratories, the U.S. supplier of oral poliovirus vaccine for the past 25 years, issued...
- Recent Outbreak of Oral Poliovirus-1 Vaccine-Derived Viral Infection in Haiti...
- Magazine article from: Infectious Disease Alert March 1, 2001 700+ words
Recent Outbreak of Oral Poliovirus-1 Vaccine-Derived Viral Infection in Haiti and the Dominican...infection with an unusual strain of mutant Sabin-derived oral poliovirus-1 (OPV-1) in the Dominican Republic and Haiti. Although...
