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Expression of pertussis toxin S1 subunit protects against pertussis toxin.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Expression of a C terminally truncated form of pertussis toxin S1 subunit effectively induces protection against pertussis toxin following DNA-based immunization.
"Four plasmids encoding different C terminally and N terminally truncated pertussis toxin S1 subunits of Bordetella pertussis were constructed and tested for inducibility of protection against pertussis toxin in mice after DNA-based immunization," investigators in Japan report.
"The region encoding an N-terminal 180-amino-acid fragment of the S1 subunit had the most potent ability to induce protective immunity," wrote Kazunari Kamachi and Yoshichika Arakawa at the National Institute of Infectious Diseases in Tokyo.
Kamachi and Arakawa published their study in Infection and Immunity (Expression of a C terminally truncated form of pertussis toxin ...
- DNA vaccine encoding pertussis toxin S1 subunit induces protection.
- Newspaper article from: Biotech Business Week January 26, 2004 700+ words
...Japan, "Pertussis toxin (PT) is...expressing the pertussis toxin S1 subunit...colleagues at the National Institute of Infectious...vaccine encoding pertussis toxin S1 subunit...Control, National Institute of Infectious...
- New strategy for allele identification of pertussis toxin genes reported.
- Newspaper article from: Vaccine Weekly January 28, 2004 700+ words
...genes coding for pertussis toxin subunit S1 (Ptx...colleagues at the National Institute of Public Health...genes coding for pertussis toxin subunit S1 (Ptx...contact Janusz Fiett, National Institute of Public Health...
- CHO cell clustering does not correlate with histamine-sensitization for...
- Newspaper article from: Vaccine Weekly February 5, 2003 700+ words
...detect a reversion to pertussis toxin (PT) toxicity...colleagues at the National Institute of Infectious Diseases...aldehyde-treated pertussis toxin (PT). Biologicals...Research on Biologics, National Institute of Infectious Diseases...
- Rapid purification method for pertussis toxin developed.
- Newspaper article from: Biotech Week June 16, 2004 700+ words
...method for the rapid purification of pertussis toxin (PT) and filamentous hemagglutinin...published research from Turkey, "Pertussis toxin (PT) and filamentous hemagglutinin...M NaCl in 50 mM phosphate buffer. Pertussis toxin and filamentous hemagglutinin purified...
- Pertussis toxin B-oligomer is pleiotropic HIV Tat inhibitor.
- Newspaper article from: Biotech Week March 31, 2004 700+ words
...com & NewsRx.net) -- The pertussis toxin B-oligomer is a pleiotropic inhibitor...demonstrated that the B-oligomer of pertussis toxin (PTX-B) inhibits HIV infection...Tat function and HIV expression by pertussis toxin B-oligomer. Eur J Immunol, 2004...
- Pertussis toxin enhances Th1 responses by stimulation of dendritic cells.
- Newspaper article from: Vaccine Weekly April 2, 2003 700+ words
...com & NewsRx.net) -- The pertussis toxin enhances Th1 responses by stimulation...the People's Republic of China, "Pertussis toxin (PTX) has been widely used as an...study in the Journal of Immunology (Pertussis toxin enhances Th1 responses by stimulation...
- Pertussis toxin validation is N. American Vaccine issue. (Blood/Biologics).
- Newspaper article from: Validation Times February 1, 2000 700+ words
...a citation for failing to produce documentation showing validation of the amount of hydrogen peroxide used to inactivate pertussis toxin. However, FDA zapped the firm for a range of other deviations as well. The agency determined that there were no records...
- Expression of a pertussis toxin S1 fragment by inducible promoters in oral...
- Magazine article from: Canadian Journal of Microbiology Mallaley, P.P. Halperin, S.A. Morris, A. MacMillan, A. Lee, S.F. May 1, 2006 700+ words
Abstract: Previous work aimed at developing a live oral vaccine expressing pertussis toxin S1 fragment on the surface of the bacterium Streptococcus gordonii elicited a lower than expected antibody response, perhaps because...
Source: HighBeam Research, Expression of pertussis toxin S1 subunit protects against pertussis...