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Antibody response by P. gingivalis and F. nucleatum modulated.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Scientists report the modulation of the antibody response by Porphyromonas gingivalis and Fusobacterium nucleatum in a mouse model in a recent issue of Oral Microbiology and Immunology.
According to a study from Australia, "Successive immunization of mice with Fusobacterium nucleatum and Porphyromonas gingivalis has been shown to modulate the specific serum IgG responses to these organisms. The aim of this study was to investigate these antibody responses further by examining the IgG subclasses induced as well as the opsonizing properties of the specific antibodies.
"Serum samples from BALB/c mice immunized with F. nucleatum (gp1-F), P. gingivalis (gp2-P), P. gingivalis followed by F. nucleatum (gp3-PF), F. nucleatum followed by P. gingivalis (gp4-FP) or saline alone (gp5-S) were examined for specific IgG1 (Th2) and IgG2a (Th1) antibody levels using an ELISA and the opsonizing properties measured using a neutrophil chemiluminescence assay."
"While IgG1 and IgG2a subclasses were induced in all immunized groups, there was a tendency towards an IgG1 response in mice immunized with P. gingivalis alone, while immunization with F. nucleatum followed by P. gingivalis induced significantly higher anti-P. gingivalis IgG2a levels than IgG1," said E. Gemmell and colleagues at the University of Queensland. "The maximum light output due to neutrophil phagocytosis of P. gingivalis occurred at 10 minutes using nonopsonized bacteria. Chemiluminescence was reduced using serum-opsonized P. gingivalis and, in particular, sera from P. gingivalis-immunized mice (gp2-P), with maximum responses occurring at 40 minutes."
"In contrast, phagocytosis of immune serum-opsonized F. nucleatum demonstrated peak light output at 10 minutes, while that of F. nucleatum ...
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