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Effect of microsphere formulation on protein immunogenicity studied.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the effect of PLA and PLGA microsphere formulation on protein immunogenicity.
"The entrapment of beta-galactosidase (Escherichia coli) in PLA and PLGA microspheres using a double emulsion technique resulted to significant reduction of protein antigenicity. The extent of antigenicity loss depended on the conditions of microsphere preparation. Most of antigenicity loss occurred on the first emulsification step. Only the effects of microsphere preparation factors having an important influence on protein antigenicity, such as the type of organic phase (polymer solvent) and homogenization, could be predicted (on a qualitative basis) by antigenicity data obtained after the first emulsification step," investigators in Greece report.
"The type of polymer and polymer solvent used to prepare the microspheres affected (C)-galactosidase immunogenicity," stated N. Stivaktakis and colleagues at the University of Patras. "The PLA microspheres prepared using ethyl acetate was the most immunogenic microsphere formulation, eliciting similar total antibody responses as the alum formulation of beta-gal. This formulation was the only microsphere formulation that induced an IgG1/IgG2a ratio lower than 1, indicating an immune response biased towards a Th1 type."
The scientists concluded, "The results obtained ...
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Source: HighBeam Research, Effect of microsphere formulation on protein immunogenicity studied.