AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Mucosal vaccine against serogroup B meningococci developed.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Bactericidal antibodies and cellular immunity were induced following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.
"Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the immunogenicity of three surface-exposed proteins from serogroup B Neisseria meningitidis (App, NhhA, and NadA) identified during whole-genome sequencing. Mice were immunized intranasally with individual proteins in the presence of wild-type Escherichia coli heat-labile enterotoxin (LTwt), LTR72, a partially inactivated mutant, or LTK63, a completely nontoxic mutant, as the adjuvant," investigators in the U.K. and Italy report.
"Each of the meningococcal proteins induced significant cellular responses; NhhA and NadA induced strong antibody responses, but only NadA induced bactericidal antibody when administered intranasally with mucosal adjuvants," said Frances Bowe at the Imperial College of Science, Technology, and Medicine in London and collaborators in the U.K. and Italy. "In addition, immunoglobulin A and bactericidal antibodies were detected in the respiratory tract following intranasal delivery of NadA. Analysis of antigen-specific cytokine production by T cells from immunized mice revealed that intranasal immunization with NadA alone failed to generate detectable cellular immune responses."
"In contrast, LTK63, LTR72, and LTwt significantly augmented NadA-specific gamma interferon, interleukin-4 ...
- NadA diversity and carriage in Neisseria meningitidis reviewed.
- Newspaper article from: Vaccine Weekly September 1, 2004 700+ words
...weak." "In conclusion, the nadA gene segregates differently...investigators. "The presence of NadA can therefore be used as a...in Infection and Immunity (NadA diversity and carriage in Neisseria...This article was prepared by Vaccine Weekly editors from staff and other...
- NADA AT A CROSSROADS: GROUP STRUGGLES TO FIND DIRECTION IN ITS RESPONSE TO...
- Magazine article from: Automotive News Harris, Donna February 2, 1999 700+ words
...for its annual convention this week. NADA faces an issue explosive enough to shatter...says Jack Pohanka, a past president of NADA and chairman of the Pohanka Automotive Group in Marlow Heights, Md. The NADA board is struggling over how to respond...
- MCCARTHY'S ROLE AT NADA: LOW PROFILE, HIGH IMPACT
- Magazine article from: Automotive News HARRIS, DONNA June 8, 1998 700+ words
...McCarthy, 63, the chief executive of NADA for 30 years, has told the board he plans...him. Under McCarthy's stewardship, NADA has flourished. It is bigger, provides...out," says Paul Holloway, chairman of NADA and president of Dreher-Holloway Inc...
- EVERYTHING TO EVERYONE: NADA STRIVES TO SERVE BOTH MOM-AND-POP STORES AND...
- Magazine article from: Automotive News Harris, Donna February 2, 1999 700+ words
...small, family-owned dealership members. NADA has been quick to notice changes in membership...But as it caters to the big players, NADA risks its longtime role as champion of...dealerships," says Paul Holloway, outgoing NADA chairman and president of Dreher-Holloway...
- What NADA did for its members in 1996. (National Automobile Dealers Association)
- Magazine article from: Automotive News Peterson, John February 3, 1997 700+ words
...But talk is cheap. Exactly what did NADA do for its 19,500 members last year...and confront key issues facing dealers, NADA beefed up its staff and research resources...Industry Relations Steering Committee. NADA's improved strategic data and information...
- AutoNation, NADA Announce Plans to Work Together on Industry Issues.
- Press release article from: PR Newswire January 20, 2003 700+ words
...than 400 AutoNation executives will sign the NADA's recently updated Code of Ethics for automobile...Operating Officer; and H. Carter Myers, III, NADA's Chairman. This also marks the first time that an NADA Chairman has attended an event hosted by...
- Compaq Steers Technology Solutions to NADA Member-Dealers Through PC Purchase...
- Press release article from: PR Newswire January 25, 2002 700+ words
NEW ORLEANS -- NADA Convention -- Today, on the eve of the NADA Annual Convention in New Orleans, Compaq Computer Corporation...Compaq to the National Automobile Dealers Association (NADA) PC Purchase Program -- a preferred technology partner...
- NADA ALERTS DEALERS ON MANUFACTURER NETWORK RESTRUCTURING AND COST SHIFTING...
- Press release article from: PR Newswire October 19, 1995 700+ words
...domestic and import manufacturers, the NADA board of directors issued the following alert to all dealer members. NADA has historically opposed any automobile...continuing to represent that manufacturer. NADA believes economic reality in a competitive...