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Method to monitor T cell responses during vaccine studies developed.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method for monitoring T cell responses during vaccine studies.
According to published research from Switzerland, "The authors developed a standardized approach for immune monitoring of antigen-specific CD8+ T cells within peripheral blood lymphocytes (PBLs) that combines direct ex vivo analysis of Melan-A/MART-1 and influenza-specific CD8+ T cells with HLA-A2/peptide multimers and interferon-gamma ELISPOT assays. Here the authors assessed the quality of results obtained with 180 PBLs from healthy donors and melanoma patients. Reproducibility of the multimer assay was good (average of 15% variation)."
"In the absence of in vivo antigen-specific T-cell responses, physiologic fluctuations of multimer-positive T cells were low, with variation coefficients of 20% for Melan-A and 28% for influenza-specific T cells," reported Daniel E. Speiser and colleagues at the Ludwig Institute for Cancer Research in Lausanne. "In contrast, patients with vaccination-induced T-cell responses had significantly increased T-cell frequencies clearly exceeding physiologic fluctuations. Comparable results were obtained with ELISPOT assays. ...
- Method to monitor T cell responses during vaccine studies developed.
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