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Hepatitis B vaccine plus lamivudine did not eliminate viral DNA.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Combined recombinant hepatitis B vaccine and lamivudine therapy did not eliminate viral DNA in a patient with chronic hepatitis B.
"We report the first case of a woman having chronic hepatitis B treated with a combination therapy of recombinant hepatitis B vaccine and lamivudine for 18 months. The main aims of such a combined therapy were to assess whether the concomitant anti-hepatitis B virus (HBV) vaccination might prevent the emergence of a mutant HBV and lead to sustained hepatitis B e antigen seroconversion with undetectable serum HBV DNA," scientists in Turkey report.
"The data from the present case demonstrated that combination of anti-HBV vaccine and lamivudine did not eliminate viral DNA despite prolonged treatment and did not have any effect on preventing resistant-type HBV," stated Kendal Yalcin and colleagues at Dicle University. "Although the combined therapy failed to reach the therapeutic endpoints, it concerned a single and unique patient. Hepatitis B ...
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