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Hsp60 plus copurified lipopolysaccharide protects against F. tularensis.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Protection afforded by heat shock protein 60 (Hsp60) from Francisella tularensis is due to copurified lipopolysaccharide.
"Heat shock proteins (Hsps) have attracted significant attention as protective antigens against a range of diseases caused by bacterial pathogens. However, more recently there have been suggestions that the protective response is due to the presence of peptide components other than Hsps. We have shown that mice that had been immunized with purified Hsp60 isolated from Francisella tularensis were protected against a subsequent challenge with some strains of the bacterium," scientists writing in the journal Infection and Immunity report.
"However, this protection appeared to be due to trace amounts of lipopolysaccharide, which were too low to be detected by using the Limulus amoebocyte lysate assay," said M. G. Hartley and colleagues at the Defense Science and Technology Laboratory. "This finding raises the possibility that the protection afforded by other bacterial ...
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Source: HighBeam Research, Hsp60 plus copurified lipopolysaccharide protects against F....