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Monocyte activation test for parenteral drug contaminants developed.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Researchers have developed a monocyte activation test for pro-inflammatory and pyrogenic contaminants of parenteral drugs.
"An optimized test designed for an in vitro monocyte activation test for pro-inflammatory and pyrogenic contaminants of parenteral drugs is described, together with ways to address the inherent variability of such assays in which cells are cultured using 96-well plates. The test preparation is cultured with peripheral blood mononuclear cells (PBMNC) and the contaminants in the test article stimulate the release from the cells of the endogenous pyrogenic cytokine interleukin-6 (IL-6)," scientists in England report.
"The test system is in use within the pharmaceutical industry and at a national control authority for detecting pro-inflammatory and pyrogenic contaminants, including 'rabbit-negative' and 'LAL-negative' non-endotoxin pyrogens," said Rose E. Gaines Das at the National Institute for Biological Standards and Control in England and collaborators in England, Switzerland, and the U.S. "Products tested include small molecules, ...
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Source: HighBeam Research, Monocyte activation test for parenteral drug contaminants developed.