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Antibodies to Cryptococcus neoformans infection are nonprotective.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Antibodies produced in response to Cryptococcus neoformans pulmonary infection in mice have characteristics of nonprotective antibodies.
According to published research from the United States, "Murine cryptocococcal pulmonary infection elicited serum immunoglobulin M (IgM) and IgG to the capsular polysaccharide, but only IgG stained yeast cells in alveoli. Both isotypes produced punctuate immunofluorescence patterns on yeast cells like those of nonprotective antibodies."
"The difficulties involved in associating humoral immunity with protection in murine cryptocococcal infection could reflect nonprotective antibody responses," wrote Oscar Zaragoza and Arturo Casadevall at the Albert Einstein College of Medicine.
Zaragoza and Casadevall published their findings in Infection and Immunity (Antibodies ...
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Source: HighBeam Research, Antibodies to Cryptococcus neoformans infection are nonprotective.