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V. cholerae polysaccharide fragments are immunogenic in mice.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Synthetic fragments of Vibrio cholerae O1 inaba O-specific polysaccharide bound to a protein carrier are immunogenic in mice but do not induce protective antibodies.
According to a study from the United States, "Development of Vibrio cholerae lipopolysaccharide (LPS) as a cholera vaccine immunogen is justified by the correlation of vibriocidal anti-LPS response with immunity. Two V. cholerae 01 LPS serotypes, Inaba and Ogawa, are associated with endemic and pandemic cholera. Both serotypes induce protective antibody following infection or vaccination. Structurally, the LPSs that define the serotypes are identical except for the terminal perosamine moiety, which has a methoxyl group at position 2 in Ogawa but a hydroxyl group in Inaba. The terminal sugar of the Ogawa LPS is a protective B-cell epitope."
"We chemically synthesized the terminal hexasaccharides of V. cholerae serotype Ogawa, which comprises in part the O-specific polysaccharide component of the native LPS, and coupled the oligosaccharide at different molar ratios to bovine serum albumin (BSA)," reported Michael D. Meeks and collaborators at Dartmouth College and the U.S. National Institutes of Health. "Our initial studies with Ogawa immunogens showed that the conjugates induced protective antibody. We hypothesized that antibodies specific for the terminal sugar of Inaba LPS would also be protective."
"Neoglycoconjugates were prepared from synthetic Inaba oligosaccharides (disaccharide, tetrasaccharide, and hexasaccharide) and BSA at ...
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Source: HighBeam Research, V. cholerae polysaccharide fragments are immunogenic in mice.