AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.

Trypomastigote challenge of T. cruzi infected mice reduces parasitemia.

Vaccine Weekly

| September 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 SEP 1 - (NewsRx.com & NewsRx.net) -- A challenge of Trypanosoma cruzi chronically infected mice with trypomastigotes activates the immune system and reduces subpatent parasitemia levels.

According to recent research from Brazil, "Challenge of 1-year Trypanosoma cruzi chronically infected mice with trypornastigotes results in a consistent reduction of parasite dissemination that correlates with spleen activation and increase in the anti-T. cruzi effector immune mechanisms. That is, parasite challenge results not only in elimination of the inoculum but also in a drastic decrease in basal subpatent parasitemia levels as revealed by transferring blood samples to immunosuppressed mice."

"Parasite elimination correlated with: a brief and intense burst in the ability of spleen cells to produce interferon-gamma, an increase in total IgG2a-producing spleen cells, higher parasite-specific IgG2a serum levels, and an accumulation of non-B, non-T class II+ cells in the spleen," reported Claudio R. F. Marinho and colleagues at the University of Sao Paulo. "Furthermore, challenged, chronically infected mice had increased numbers of B, CD4+, and CD8+ large spleen cells. Besides reinforcing the activation of protective Th1 effector mechanisms, challenge with T. cruzi also induced Th2 effector molecules, such as interleukin (IL)-10 and IL-4, and ...

Related articles from newspapers, magazines, journals, and more
Study data from University of Sao Paulo, Institute of Biomedical Science update...
Newspaper article from: Blood Weekly March 5, 2009 700+ words
...cells," scientists in Sao Paulo, Brazil report (see...of L. braziliensis-infected mice with tamoxifen resulted...colleagues, University of Sao Paulo, Institute of Biomedical...Miguel, Universidade de Sao Paulo, Dept. of Parasitology...
Data on life sciences discussed by researchers at University of Sao...
Newspaper article from: Biotech Week September 10, 2008 700+ words
...Foxp3+ T cells migrate to the heart of infected mice. The treatment with anti-CD25 or anti...Mariano and colleagues, University of Sao Paulo (see also Life Sciences). The researchers...contact F.S. Mariano, University of Sao Paulo, Dept. of Biochemistry and Immunology...
Sao Paulo.(BEST OF BRAZIL)(Restaurant review)
Rio & the Best of Brazil Alive January 1, 2007 700+ words
It may seem odd to place Sao Paulo, the largest city in Brazil, at...this. Virtually all travelers to Sao Paulo are here on business. The city has...have been replaced by sky scrapers. Sao Paulo does not have the lure of Rio's...
Sao Paulo beats Atletico 4-0 to win third Copa Libertadores title.
News wire article from: The America's Intelligence Wire July 15, 2005 700+ words
...scored and set up another goal to help Sao Paulo defeat Atletico Paranaense 4-0 and...the southern city of Porto Alegre, and Sao Paulo took advantage of the nearly 75,000...aggregate score. After the final whistle, Sao Paulo players jumped and celebrated at midfield...
Internacional 2, Sao Paulo 2.
News wire article from: The America's Intelligence Wire August 17, 2006 700+ words
...Wednesday when it held defending champion Sao Paulo to a 2-2 draw. Combined with Internacional...substitute midfielder Lenilson scored for Sao Paulo, while striker Fernandao and midfielder...title," Inter coach Abel Braga said. Sao Paulo was trying to win the tournament for...
Copa Libertadores: Internacional beats Sao Paulo 2-1 in final's first leg.
News wire article from: The America's Intelligence Wire August 10, 2006 700+ words
...half goals and Internacional defeated Sao Paulo 2-1 in the first leg of the all-Brazilian...penalty spot after a clearing header by Sao Paulo defender Junior rebounded off the crossbar...muscle injury. Defender Edcarlos netted Sao Paulo's lone goal with a firm header in the...
Rubella immunization strategies in the state of Sao Paulo, Brazil.(Letter to...
Magazine article from: Bulletin of the World Health Organization Rymkiewicz, Erika Colla, Fausto Zuzarte, Cortesao Campos, Sandra de Oliveira Pinto, Maria Isabel de Moraes March 1, 2002 700+ words
...years of age was launched in the state of Sao Paulo in 1992, through which the measles...syndrome (CRS) cases in the state of Sao Paulo has decreased considerably. However...5% of rubella cases in the state of Sao Paulo occurred in individuals aged 20-29...
Libertadores: Sao Paulo beats Brazilian rival Palmeiras 1-0.
News wire article from: The America's Intelligence Wire May 19, 2005 700+ words
...through the second half Wednesday to lead Sao Paulo over Palmeiras 1-0 in the first leg...second-round Copa Libertadores match. Sao Paulo needs only a draw in the second leg next...match during most of the first half, but Sao Paulo was able to even things in the second...
Brazil: Roundup of Roofless Movement Dwellers occupy properties in Sao Paulo...
News wire article from: Asia Africa Intelligence Wire April 21, 2004 700+ words
...contents further. PEOPLE'S LOW-INCOME HOUSING MOVEMENT STAGE OCCUPATIONS IN SAO PAULO - An Article by Angelica Freitas in today's Sao Paulo O Estado de Sao Paulo states that "Over 7,000 people linked to the Peoples' Low-Income Housing...
Sao Paulo: Urbanization Run Amok.(economic problems of Sao Paulo, Brazil)
Magazine article from: World and I Henkin, Stephen August 1, 1999 700+ words
...the myriad difficulties now plaguing Sao Paulo, Brazil. With 21.4 million residents...resembles the satellite communities of Sao Paulo in the 1960s, which came together in...CONTRASTS A city of stark contrasts, Sao Paulo has a business-development side that...
For more facts and information, see all results

Source: HighBeam Research, Trypomastigote challenge of T. cruzi infected mice reduces...

©2009 Gale, a part of Cengage Learning. All rights reserved.
About us | FAQs | Contact us | Privacy policy | Terms and conditions
Other Gale sites: Encyclopedia.com | HighBeam Research | Acquire Content | Books & Authors | Goliath | MovieRetriever | Smart QandA