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2004 SEP 1 - (NewsRx.com & NewsRx.net) -- A challenge of Trypanosoma cruzi chronically infected mice with trypomastigotes activates the immune system and reduces subpatent parasitemia levels.
According to recent research from Brazil, "Challenge of 1-year Trypanosoma cruzi chronically infected mice with trypornastigotes results in a consistent reduction of parasite dissemination that correlates with spleen activation and increase in the anti-T. cruzi effector immune mechanisms. That is, parasite challenge results not only in elimination of the inoculum but also in a drastic decrease in basal subpatent parasitemia levels as revealed by transferring blood samples to immunosuppressed mice."
"Parasite elimination correlated with: a brief and intense burst in the ability of spleen cells to produce interferon-gamma, an increase in total IgG2a-producing spleen cells, higher parasite-specific IgG2a serum levels, and an accumulation of non-B, non-T class II+ cells in the spleen," reported Claudio R. F. Marinho and colleagues at the University of Sao Paulo. "Furthermore, challenged, chronically infected mice had increased numbers of B, CD4+, and CD8+ large spleen cells. Besides reinforcing the activation of protective Th1 effector mechanisms, challenge with T. cruzi also induced Th2 effector molecules, such as interleukin (IL)-10 and IL-4, and ...
Source: HighBeam Research, Trypomastigote challenge of T. cruzi infected mice reduces...