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Thymus-leukemia antigen acts as tumor-specific antigen.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Researchers are investigating thymus-leukemia antigen (TL) as a major histocompatibility complex (MHC) class lb molecule and tumor-specific antigen.
According to recent research from Japan, "Mouse thymus-leukemia antigens (TL) belong to the family of major histocompatibility complex (MHC) class lb antigens and have a unique mode of expression, i.e., in contrast to other MHC class lb or la antigens, they are found restricted to the intestines in all mouse strains, but also in the thymus of certain strains (TL+ strains). Nevertheless, a proportion of T lymphomas/leukemias in strains that do not express TL in the thymus (TL- strains) feature TL as a tumor antigen."
"TL was originally defined serologically, but subsequently we have succeeded in generating T cell receptor (TCR) alphabeta and gammadelta cytotoxic T lymphocytes [CTL) recognizing TL," said Kunio Tsujimura and collaborators at the Aichi Cancer Center Research Institute and the RIKEN BioResource Center. "By use of TL tetramers free from peptides and transfectants expressing various TL/H-2 chimeric molecules, we have been able to show that TL-specific CTL recognize the alpha1/alpha2 domain of TL without any additional antigen molecules. We previously reported that one of TL's functions in the thymus is positive selection of TCRgammadelta CTL."
The researchers reported, "Recent studies with TL tetramers revealed that they can bind to normal intestinal intraepithelial lymphocytes (iIEL) and thymocytes in a CD8-dependent, but TCR/CD3-independent manner, ...
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Source: HighBeam Research, Thymus-leukemia antigen acts as tumor-specific antigen.