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Exosomes from plasmacytoma cells show promise as tumor vaccine.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Exosomes from plasmacytoma cells show promise as a tumor vaccine.
"Exosomes are membrane-bound vesicles derived from multivesicular bodies that are externalized by cells through fusion with the plasma membrane. Exosomes have been implicated in cell-to-cell signaling, and those derived from immunologic cells may be involved in both direct and cross-presentation of antigens to T cells. The research presented here evaluated their efficacy as a prophylactic cancer vaccine in a mouse plasmacytoma model," scientists in the United States report.
"Plasmacytoma cells were shown to release exosomes in vitro, and vaccination with a single dose (5 microgram) of exosome protein protected 80% of mice against challenge with wild-type tumors," stated Stephen L. Altieri and colleagues at the Roswell Park Cancer Institute. "Protection could be linked to the immune system since vaccinated mice generated specific cytotoxic T lymphocytes, the effects were not seen in SCID mice, and immunity was tumor-specific. Several proteins involved in immunity, including two potential tumor antigens (PIA and intracisternal A particle protein) as ...
- Blood Exosomes Contain Tumor-Specific Genetic Brain Cancer Information.
- Newspaper article from: BIOTECH Patent News November 1, 2008 700+ words
Tiny vesicles called exosomes released into the bloodstream from...this important cancer signature from exosomes circulating in blood is a critical...officer of Exosome Diagnostics. "Exosomes offer us the possibility of diagnosing...
- Blood Exosomes Shown to Contain Tumor-Specific Genetic Information for Brain...
- Press release article from: PR Newswire November 17, 2008 700+ words
...PRNewswire/ -- Tiny vesicles called exosomes released into the bloodstream from aggressive...this important cancer signature from exosomes circulating in blood is a critical demonstration...executive officer of Exosome Diagnostics. "Exosomes offer us the possibility of diagnosing...
- Intestinal epithelial exosomes carry MHC class II/peptides able to inform the...
- Magazine article from: Gut Van Niel, G. Mallegol, J. Bevilacqua, C. Candalh, C. Brugiere, S. Tomaskovic-Crook, E. Heath, J.K. Cerf-Bensussan, N. Heyman, M. December 1, 2003 700+ words
...characterise murine intestinal epithelial exosomes and to analyse their capacity to inform...in vivo in mice. Methods: Epithelial exosomes were obtained from the murine epithelial...hOVA) to mimic luminal digestion. Exosomes isolated from MODE K conditioned media...
- Exosomes transfer functional MHC class I/peptide complexes to dendritic cells.
- Newspaper article from: Immunotherapy Weekly April 28, 2004 700+ words
...NewsRx.net) -- Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes...Because DC can secrete MHC class I-bearing exosomes, we addressed whether exosomes pulsed with synthetic peptides could subserve...
- Anosys testing exosomes as anticancer vaccine vectors.
- Newspaper article from: BioWorld International Etheridge, James December 4, 2002 700+ words
PARIS -- A technology that uses exosomes derived from immune system cells as vectors...T cells by dendritic cell-derived exosomes" in the December 2002 edition of Nature...as well as to other patents covering exosomes held by the Dutch universities in Leiden...
- Proteomic analysis of exosomes secreted by mesothelioma cells reported.
- Newspaper article from: Drug Week July 16, 2004 700+ words
...the results of a proteomic analysis of exosomes secreted by human mesothelioma cells...the American Journal of Pathology. "Exosomes are small membrane vesicles secreted...extracellular compartment by exocytosis. Tumor exosomes may be involved in the sampling of antigens...
- Exosomes act as potent cell-free peptide-based vaccines.
- Newspaper article from: Biotech Week April 21, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Exosomes act as potent cell-free peptide...responses. Dendritic cell-derived exosomes could be considered as novel peptide-based vaccines because exosomes harbor a discrete set of proteins...
- Production and characterization of clinical grade exosomes described.
- Newspaper article from: Vaccine Weekly January 8, 2003 700+ words
...characterization of clinical grade (cGMP) exosomes derived from antigen presenting cells (APCs)." "Exosomes have been shown to have immunotherapeutic...H.G. Lamparski and colleagues. "Exosomes are 50-90 nm-diameter vesicles secreted...
- New Treatment of Rheumatoid Arthritis With Anti-Inflammatory Exosomes.
- Press release article from: PR Newswire March 14, 2006 700+ words
...compounds are called "anti-inflammatory exosomes". The treatment of 66 patients with RA proved successful using this technology. Exosomes are cell particles of white blood cells...Orthopedics, Dusseldorf, Germany said: "Exosomes teach the immune system to recognize...
- Circulating exosomes sustain the hepatitis C virus life cycle.
- Newspaper article from: Biotech Week December 29, 2004 700+ words
...amp; NewsRx.net) -- Circulating exosomes sustain the hepatitis C virus life cycle...found extracellularly associated with exosomes," according to F. Masciopinto and...also report that human plasma contains exosomes and that in HCV patients, viral RNA...
Source: HighBeam Research, Exosomes from plasmacytoma cells show promise as tumor vaccine.