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Epithelial cancer-related antigens applicable for peptide-based immunotherapy.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Investigators review the expression of epithelial cancer-related antigens in hematologic malignancies applicable for peptide-based immunotherapy in a recent issue of the Journal of Immunotherapy.
According to published research from Japan, "Recent advances in tumor immunology have resulted in identification of many epithelial cancer-related antigens and peptides applicable to specific immunotherapy. The authors investigated whether these peptides, which are being studied clinically, could be appropriate target molecules for treatment of patients with hematologic malignancies. The majority of hematologic malignant cells studied expressed five different epithelial cancer-related antigens."
"Cytotoxic T lymphocyte (CTL) precursors reactive to these antigen-derived peptides were detected in peripheral blood mononuclear cells (PBMCs) of the majority of HLA-A24+ patients, and the mean number of peptides recognized by CTL precursors was 2.4 per patient, ranging from 0 to 8 among the 10 peptides tested," reported Hiroko Takedatsu and colleagues at Kurume University. "These peptide-stimulated PBMCs exhibited HLA-A24-restricted cytotoxic activity against hematologic malignant cells but not against blastoid T cells. More importantly, these peptide-stimulated ...
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- Peptide vaccine candidates for use in epithelial cancer patients reported.
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...candidates for use in HLA-A31+ epithelial cancer patients. According to recent research...candidates for use in HLA-A31+ epithelial cancer patients. Int J Oncol, 2004;24...under the major subject areas of Epithelial Cancer, Cancer Vaccine, Vaccine Development...
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...Our data also indicates a progression in the process of epithelial cancer development, as benign leukoplakia was diagnosed 2-4...under the major subject areas of Oncology, Oral Cancer, Epithelial Cancer, Leukoplakia, Squamous Cell Carcinoma, Non-Hodgkin...
- Acute appendicitis: an unusual cause.(epithelial cancer of the ovary)
- Magazine article from: Postgraduate Medical Journal Clark, S K Qureshi, T Sen, M February 1, 2001 700+ words
...paclitaxel or cyclophosphamide) [1] is indicated. Discussion Epithelial cancer of the ovary is characterised by exfoliation of malignant...Sonnendecker HE. Involvement of the appendix in ovarian epithelial cancer-an update. S Afr Med J 1989;76:667-8. (4...
- Epithelial Cancer of the Ovary.
- Magazine article from: British Medical Journal Steel, C. Michael January 27, 1996 700+ words
...whether there is a place for another, even one that boasts a distinguished and international list of contributors. In fact Epithelial Cancer of the Ovary marks out a distinctive position for itself. It certainly does not neglect basic cell and molecular biology...
- Monoclonal antibody therapy in treating patients with ovarian epithelial...
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...NCI). This phase I trial is studying the side effects of monoclonal antibody therapy in treating patients with ovarian epithelial cancer, melanoma, acute myeloid leukemia, myelodysplastic syndrome, or nonsmall cell lung cancer. Condition Intervention...
- Epithelial cancer mucin antigens: the products of abnormal glycosylation....
- Newspaper article from: Cancer Weekly Taylor-Papadimitriou, J. March 29, 1993 700+ words
AUTHORS: J. Taylor-Papadimitriou. 44 Lincoln's Inn Fields, London, U.K. According to an abstract presented by the author to the Specific Immunotherapy of Cancer Vaccines Conference, held January 21-24, 1993, in Washington, D.C., "At least 5 different genes coding for mucin core proteins have been
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- Newspaper article from: Pain & Central Nervous System Week August 2, 2004 700+ words
2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Researchers seeking to direct cancer-killing immune cells against the deadliest brain tumors have three new targets that show promise in laboratory studies and in a Phase I patient trial, according to two studies. The antigens, previously associated
- New cancer gene therapy data have been reported by scientists at University of...
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...causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor...that RHBDF1 function is essential to epithelial cancer cell growth. RHBDF1 mRNA level is...role in sustaining growth signals in epithelial cancer cells and thus may serve as a therapeutic...
- HER2/neu peptides recognized by cellular and humoral immune systems.
- Newspaper article from: Biotech Week May 26, 2004 700+ words
...its expression in various types of epithelial cancer. HER2/neu can also be a target...patients with various types of epithelial cancer," concluded the scientists. Ishihara...under the major subject areas of Epithelial Cancer, Immunology, Proteomics, and Oncology...
Source: HighBeam Research, Epithelial cancer-related antigens applicable for peptide-based...