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Antigen-loading strategies of dendritic cells for cancer vaccines compared.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Investigators compare antigen-loading strategies of dendritic cells for tumor immunotherapy in a recent issue of the Journal of Immunotherapy.
"Dendritic cells (DCs) loaded with antigens can effectively stimulate host immune responses to syngeneic tumors, but there is considerable controversy as to which forms of antigen-loading are most immunogenic. Here, the authors compared immunotherapeutic reactivities of DCs loaded with a variety of antigen preparations. Because DC maturation stages affect their capacities of antigen processing and presentation, two DC populations were used for the current analysis: in vivo Flt-3 ligand-induced mature DCs and in vitro bone marrow-derived DCs, which were less mature," researchers in the United States report.
"To facilitate a direct comparison, the LacZ gene-transduced B16 melanoma model system was used, where beta-galactosidase served as the surrogate tumor-rejection antigen," said Kenji Shimizu and colleagues at the Cleveland Clinic. "DC loading strategies included pulsing with the beta-galactosidase protein, H-2K[superscript]b restricted peptide, tumor cell lysate, and irradiated tumor cells and fusion of DCs with tumor cells. Our results demonstrated that electrofusion of DCs and tumor cells generated a therapeutic vaccine far superior to other methods of DC loading."
"For the treatment of 3-day established pulmonary tumor nodules, a single intranodal vaccination ...
- Dendritic cells exposed to human immunodeficiency virus type-1 transmit a...
- Newspaper article from: AIDS Weekly August 10, 1992 700+ words
...387. Superantigen-presenting dendritic cells carrying HIV virions cause an "explosive...infected with HIV. HIV-bearing blood dendritic cells could cause extensive loss of previously...lymphoid organs, where follicular dendritic cells come into contact with high numbers...
- Dendritic cells tied to psoriasis.(News)
- Magazine article from: Skin & Allergy News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...published since 2003) suggest that dendritic cells also play a role. Researchers believe...
- IL-10-treated dendritic cells may induce GVHD risk.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...amp; NewsRx.net) -- Dendritic cells treated with interleukin...IL-10-treated immature dendritic cells in the first mixed leukocyte...were cultured with mature dendritic cells of the same origin as IL...
- FLT3 LIGAND STIMULATES GROWTH OF DENDRITIC CELLS
- Press release article from: PR Newswire November 30, 1995 700+ words
...been shown to promote the growth of dendritic cells, a formerly elusive type of cell...now, research into the utility of dendritic cells has been hampered because these cells...large numbers of functionally mature dendritic cells. "Dendritic cells could be quite...
- Scientists describe how dendritic cells grow up to take on foreign invaders.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...Acting as the body's sentinels, dendritic cells are constantly on the lookout for...yet to be explained, only mature dendritic cells process and accumulate these threatening...fueled an interest in using activated dendritic cells to fight cancer and other diseases...
- Future psoriasis drugs may target role of dendritic cells.(Rx)
- Magazine article from: Internal Medicine News McNamara, Damian March 1, 2006 700+ words
...FLA. -- Recent research implicates dendritic cells in the pathogenesis of psoriasis and...promise by halting cytokines produced by dendritic cells, he noted. Psoriasis is widely known...been published since 2003) suggest dendritic cells also play a role by activating the...
- Decidual CD83+ dendritic cells implicated in some recurrent miscarriages.
- Magazine article from: Women's Health Weekly April 15, 2004 700+ words
...NewsRx.net) -- Decidual CD83+ dendritic cells may contribute to some cases of recurrent...Potent immunostimulatory (CD83) dendritic cells have recently been identified in the...sought to determine "whether decidual dendritic cells could play a role in the etiology...
- IMMUNE SYSTEM: Glowing Dendritic Cells in Action.
- Newspaper article from: Cell Therapy News September 1, 2002 700+ words
...may work their way to the surface of live dendritic cells. Dendritic cells are immune cells that alert T-cells and...Medical School. Because of this activity, dendritic cells are being exploited by several companies...
- Dendritic Cells Offer New Therapeutic Target for Drugs to Treat Multiple...
- News wire article from: Europe Intelligence Wire November 29, 2005 700+ words
...confirmed that the gene is activated in dendritic cells, whose role is to distribute "look...block FLT3 gene signaling could stop dendritic cells from triggering harmful responses...investigators believe that targeting dendritic cells may stop the faulty immune response...
- Researcher summarizes the promise of dendritic cells.
- Newspaper article from: Immunotherapy Weekly December 18, 2002 700+ words
...the current status of knowledge of dendritic cells, a class of white blood cells that...AIDS. Cancer vaccines composed of dendritic cells bearing pieces of cancer tumor from...published in Scientific American. Dendritic cells exist in many tissues, particularly...
Source: HighBeam Research, Antigen-loading strategies of dendritic cells for cancer vaccines...