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Vaccine protects mice against virulent Brucella melitensis.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Oral vaccination with Brucella melitensis WR201 protects mice against intranasal challenge with virulent Brucella melitensis 16M.
"Human brucellosis can be acquired from infected animal tissues by ingestion, inhalation, or contamination of conjunctiva or traumatized skin by infected animal products. In addition, Brucella is recognized as a biowarfare threat agent. Although a vaccine to protect humans from natural or deliberate infection could be useful, vaccines presently used in animals are unsuitable for human use," scientists writing in the journal Infection and Immunity report.
"We tested orally administered live, attenuated, purine auxotrophic B. melitensis WR201 bacteria for their ability to elicit cellular and humoral immune responses and to protect mice against intranasal challenge with B. melitensis 16M bacteria," said Mina J. Izadjoo and collaborators at the Walter Reed Army Institute of Research and the Armed Forces Institute of Pathology in the U.S. "Immunized mice made serum antibody to lipopolysaccharide and non-O-polysaccharide antigens. Splenocytes from immunized animals released IL-2 and gamma interferon when grown in cultures with Brucella antigens. Immunization led to protection from disseminated infection and enhanced clearance of the challenge inoculum from the ...
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Source: HighBeam Research, Vaccine protects mice against virulent Brucella melitensis.