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Peptides inducing immune responses in breast cancer patients identified.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Scientists have identified HER2/neu-derived peptides capable of inducing both cellular and humoral immune responses in HLA-A24 positive breast cancer patients.
"HRE2/neu-specific cellular and humoral immune responses are often detected in breast cancer patients, but identification of more immunogenic CTL epitope peptides is necessary prior to development of a cancer vaccine. There is accumulating evidence of strong immunogenicity of peptides capable of inducing both cellular and humoral immune responses. To identify such peptides, this study intended to determine HER2/neu-derived peptides capable of inducing both cellular and humoral immunity in HLA-A24+ breast cancer patients," investigators in Japan report.
"IgGs reactive to the HER2[subscript]342-350, HER2[subscript]485-493, and HER2[subscript]553-561 peptides were detected in the sera of these patients with the frequency of 47, 24, and 24%, respectively," said Koichi Azuma and colleagues at Kurume University. "These peptides also induced peptide-specific and tumor-reactive CTL activity in the peripheral blood mononuclear cells of HLA-A24+ breast cancer patients with the frequency of 50, 63, and 25%, respectively, but such activity was not induced from any HLA-A24- patients. Cellular and humoral responses to each ...
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- Peptides inducing immune responses in breast cancer patients identified.
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...responses in HLA-A24 positive breast cancer patients. "HRE2/neu-specific...responses are often detected in breast cancer patients, but identification of...immunity in HLA-A24+ breast cancer patients," investigators in Japan...
