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Quaternary ammonium compounds exhibit adjuvant effect in murine model.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Quaternary ammonium compounds exhibit an adjuvant effect in a murine model.
"It has been suggested that occupational exposure to quaternary ammonium compounds (QACs) may promote the development of allergic airway diseases. In this study, hazard identifications of the adjuvant effect of cetylpyridinium chloride (CPC), dimethy1dioctadecylammonium bromide (DDA), hexadecyltrimethylammonium bromide (HTA), and tetraethylammonium chloride (TEA) were performed in a screening bioassay. Female BALB/c mice were injected subcutaneously with the model allergen ovalbumin (OVA) alone or together with different quantities of one of the QAC test compounds," scientists writing in the journal Toxicology Letters report.
"After one or two boosters, levels of OVA-specific IgE, IgG1, and IgG2a antibodies were measured in sera," stated Soren T. Larsen and colleagues at the National Institute of Occupational Health in Copenhagen. "CPC and DDA increased IgE and IgG1 antibody production, respectively, compared to the OVA control group, whereas HTA and TEA showed no adjuvant effect. Nevertheless, when TEA ...
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Source: HighBeam Research, Quaternary ammonium compounds exhibit adjuvant effect in murine model.