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2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Researchers outline challenges in the search for an HIV vaccine in a recent issue of the European Journal of Epidemiology.
"Considerable progress has been made over the past several years in the development of an HIV vaccine. As a result, a growing number of vaccine modalities are being investigated in pre-clinical and phase I/II clinical trials. However, a number of major scientific challenges still remain," investigators in the Netherlands and the United States report.
"It is widely believed that the ideal vaccine should elicit both neutralizing antibodies and cytotoxic T lymphocytes (CTL) against diverse isolates of HIV, but the precise correlates of immunity have not been defined," said Angelique A. C. Lemckert and collaborators at Crucell Holland BV in the Netherlands and Harvard University in the U.S. "Recombinant live vector-based vaccines and plasmid DNA vaccines have been shown to induce CTL, either alone or in combination, and these CTL-based vaccines have shown ...
Source: HighBeam Research, Challenges in the search for HIV vaccine outlined.