AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Prion protein domains elicit antibody responses against native molecule.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Scientists have identified two immunogenic domains of the prion protein PrP, which activate class II-restricted T cells and elicit antibody responses against the native molecule.
"Recent reports suggest that immunity against the prion protein (PrP) retards transmissible spongiform encephalopathies progression in infected mice. A major obstacle to the development of vaccines comes from the fact that PrP is poorly immunogenic, as it is seen as self by the host immune system. Additional questions concern the immune mechanisms involved in protection and the risk of eliciting adverse reactions in the central nervous system of treated patients," researchers in France report.
"Peptide-based vaccines offer an attractive strategy to overcome these difficulties," said Sylvie Gregoire and collaborators at INSERM E209, SEDAC Therapeutics, and the University of Paris. "We have undertaken the identification of the immunogenic regions of PrP, which trigger helper T cells (Th) associated with antibody production. Our results identify two main regions, one between the structured and flexible portion of PrP (98-127) and a second between alpha 1 and alpha 2 helix (143-187). Peptides (30-mer) corresponding ...
- Tolerance to prion protein broken by prion protein peptides and ODN-CpG.
- Newspaper article from: Vaccine Weekly June 30, 2004 700+ words
...of infectious agents, the prion protein (PrP), is a self antigen...Breaking immune tolerance to the prion protein using prion protein peptides plus oligodeoxynucleotide...This article was prepared by Vaccine Weekly editors from staff and other...
- Antigens of abnormal isoform of prion protein characterized.
- Newspaper article from: Vaccine Weekly June 2, 2004 700+ words
...pathogenic isoform of prion protein (PrP[superscript]Sc) or recombinant prion protein (rPrP). The mAbs...abnormal isoform of prion protein using a new diverse...article was prepared by Vaccine Weekly editors from staff...
- Helix 1 peptide elicits antibodies against prion protein in mice.
- Newspaper article from: Vaccine Weekly January 21, 2004 700+ words
...antibodies against prion protein in BALB/c mice using...recognize the whole prion protein with a high binding...antibodies against prion protein in wild-type mice...article was prepared by Vaccine Weekly editors from staff...
- Accumulation of prion protein in tonsil and appendix: review of tissue samples....
- Magazine article from: British Medical Journal Hilton, David A Ghani, Azra C Conyers, Lisa Edwards, Philip McCardle, Linda Penney, Mark Ritchie, Diane Ironside, James W September 21, 2002 700+ words
...and the inability to detect abnormal prion protein in blood has hampered the development...1) Lymphoreticular accumulation of prion protein has been used as a preclinical test...tonsillectomies for the presence of prion protein in lymphoreticular tissue to determine...
- Study confirms prion protein as therapeutic target in CJD.
- Newspaper article from: BioWorld International Kingman, Sharon February 7, 2007 700+ words
...all the naturally occurring normal prion protein in the brain, a study in mice suggested...nerve cells stop expressing the native prion protein at about 9 weeks of age, researchers...genetic engineering to inactivate the prion protein, and critically, we need a test for...
- Prion protein in Mad Cow disease studied.
- News wire article from: UPI NewsTrack September 29, 2008 700+ words
...veterinary scientists are studying the prion protein, known for its role in mad cow disease...production and accumulation of the prion protein in the brains of cattle with a rare...that while the misfolded form of the prion protein that accumulates in the brains of BSE...
- Human prion protein rescues PrP null phenotype in transgenic mice.
- Newspaper article from: Proteomics Weekly July 12, 2004 700+ words
...NewsRx.net) -- Pathogenic human prion protein rescues PrP null phenotype in transgenic...are caused by coding mutations in the prion protein (PrP) gene. We investigated whether...results in a functionally inactive prion protein by expressing human PrP 200K in transgenic...
- Inherited prion disease with A117V mutation of the prion protein gene: a novel...
- Magazine article from: Journal of Neurology, Neurosurgery and Psychiatry Kovacs, G G Ertsey, C Majtenyi, C Jelencsik, I Laszlo, L Flicker, H Strain, L Szirmai, I Budka, H June 1, 2001 700+ words
...was evident. Immunostaining for the prion protein disclosed unicentric and multicentric...positivity. Genetic analysis of the prion protein gene of the propositus showed a 117...mutations and insertions within the prion protein gene (PRNP) form the genetic background...
- Prion protein gene sequence of Canada's BSE case determined.
- Newspaper article from: Proteomics Weekly March 1, 2004 700+ words
...net) -- Researchers report the prion protein gene sequence of Canada's first non...sequence data from the affected animal's prion protein coding sequence that argue definitively...results of their research in Genome (Prion protein gene sequence of Canada's first non...
- Prion protein undergoes alpha- and beta- cleavages of amino-terminus.
- Newspaper article from: Drug Week June 25, 2004 700+ words
...amp; NewsRx.net) -- The cellular prion protein undergoes alpha- and beta- cleavages...assumed that the physiological isoform of prion protein, PrP[superscript]C, is cleaved...the amino-terminus of the cellular prion protein. Bio Cell, 2004;96(2):125...
Source: HighBeam Research, Prion protein domains elicit antibody responses against native...