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Killed nonencapsulated cells protect mice against pneumococcal colonization.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Killed nonencapsulated cells given intranasally with a nontoxic adjuvant protected mice against pneumococcal colonization of the nasopharynx and middle ear.
According to a study from the United States and Brazil, "Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites."
"Of four nontoxic adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically protective," wrote Richard Malley and collaborators at Harvard University and the University of Rochester in the U.S. and the University of Sao Paulo in Brazil.
Malley and his coauthors published the results of their research in Infection and Immunity (Multiserotype protection of mice against ...