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Immunization protects dopaminergic neurons in model of Parkinson disease.
2004 SEP 1 - (NewsRx.com & NewsRx.net) -- Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson disease.
According to a study from the United States, "Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantial nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor."
"This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells," reported Eric J. Benner and collaborators at the University of Nebraska and Columbia University. "Such vaccine treatment strategies may provide benefit for Parkinson disease."
Benner and colleagues ...
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Source: HighBeam Research, Immunization protects dopaminergic neurons in model of Parkinson...