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Knockout mouse created as model of female infertility.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Researchers with the U.S. National Institutes of Health (NIH) have created a mouse model of female infertility.
In mammals, the development of the egg in the ovary is halted until just before ovulation, at which point the final cellular division to form the egg, called meiosis, is completed. Researchers have shown that this final step in egg maturation can be blocked by a chemical called cyclic AMP (cAMP) in a test tube, but it remained uncertain whether the same molecular mechanism occurred in the animal.
To investigate this process, Vincent Manganiello and colleagues at the NIH created a mouse that is missing a gene for a protein whose function is to breakdown cAMP in the developing egg. This gene is called cyclic nucleotide phosphodiesterase 3A, or Pde3a. Male mice that are missing their Pde3a gene are healthy and completely fertile. Female mice without the Pde3a gene are likewise healthy and can carry out ...
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- Magazine article from: Women's Health Weekly July 29, 2004 700+ words
...investigate this process, Vincent Manganiello, of the U.S...corresponding author is Vincent Manganiello, ManganiV@nhlbi...prepared by Women's Health Weekly editors from staff...2004, Women's Health Weekly via NewsRx.com...
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