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HRT could have more benefits than risks when started early in menopause.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Do not categorically reject hormone replacement therapy (HRT) just yet: When women begin HRT before age 60, their risk of death is 39% less than women not on hormones, according to a new study.
The findings are based on a Cornell University-Stanford University meta-analysis (a study of other previously published studies), which pooled the results of 30 clinical trials of HRT with almost 27,000 women.
"The results of our analysis indicate that the benefits of HRT outweigh the risks in women who have recently entered menopause," says Edwin E. Salpeter, who did the statistical analyses for the study. Salpeter is a professor of physics emeritus at Cornell and a 1997 Crafoord Prize laureate who has turned his interest to medical issues in recent years.
The first author of the study, which was published in the July 2004 issue of the Journal of General Internal Medicine (2004;19:7), is his daughter, Shelley R. Salpeter, MD, a clinical professor of medicine at Stanford University School of Medicine and a physician at Santa Clara Valley Medical Center in San Jose, California.
The new findings appear contrary to two large, well-publicized studies, the Heart and Estrogen/Progestin Replacement Study and the Women's Health Initiative, which found no difference in mortality rates for those taking HRT or a placebo. Women taking HRT, these two studies found, had increases in breast cancer, stroke, heart attacks and pulmonary embolism and decreases in colon cancer, hip fractures and diabetes mellitus. The conclusion from these trials was that the risks of HRT outweighed the benefits in these patients. These findings, however, were based on samples of women whose mean age was 65 years at the start of the trial.
Shelly Salpeter points to an earlier survey, the Nurses' Health Study, "a large prospective study that found that women who started treatment within 2 years of menopause had a total mortality risk of 0.63 that of nonusers." She adds ...
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Source: HighBeam Research, HRT could have more benefits than risks when started early in...