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SLN biopsy practicable for diagnosing cervical, endometrial cancers.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Sentinel lymph node biopsy is feasible as a tool for diagnosing cervical and endometrial cancer, suggest physicians at the Hopital Europeen Georges Pompidou, Paris, France.
"The sentinel lymph node (SLN) biopsy has been proposed for the cancers of the uterus in order to optimize the diagnosis of lymphatic metastases and micrometastases in early stage tumors," said L. Lelievre and colleagues.
Lelievre's group enrolled 8 women with early invasive cervical cancer and 15 with endometrial cancer in a study of SLN biopsy for this purpose.
First each patient underwent a lymphoscintigraphy. Then "[i]ntraoperative SLN identification was performed with blue dye combined to a handheld gamma probe detection. Nonsentinel pelvic nodes were separately cleared out. SLNs were examined with frozen sections, permanent sections with hematoxylin-eosin staining and further serial sections with immunohistochemistry if negative," the researchers explained.
"Six cervical cancer patients and 13 endometrial cancer patients had a positive lymphoscintigraphy, showing in 5 patients extra-iliac SLN(s)," reported Lelievre and coworkers.
"The intraoperative detection was successful in 6 cervical cancer patients and 74 endometrial cancer patients," they said, ...
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Source: HighBeam Research, SLN biopsy practicable for diagnosing cervical, endometrial cancers.