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Methylated DNA collected by tampons detects endometrial cancer.

Women's Health Weekly

| August 05, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Methylated DNA collected by tampons detects endometrial cancer.

According to recent research published in the journal Cancer Epidemiology Biomarkers & Prevention, "This proof of principle study aimed to define a new and simple strategy for detection of endometrial cancer using epigenetic markers."

"We investigated DNA isolated from vaginal secretion collected from tampon for aberrant methylation of five genes (CDH13, HSPA2, MLH1, RASSF1A and SOCS2) using MethyLight in 15 patients with endometrial cancer and 109 patients without endometrial cancer.

"All endometrial cancer patients revealed three or more methylated genes," H. Fiegl and coworkers reported, "whereas 91% (99 of 109) of the patients without endometrial cancer had no or fewer than three genes methylated in their vaginal secretion."

"The methods developed in this study provide the basis for a prospective clinical trial to screen asymptomatic women who are at ...

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Source: HighBeam Research, Methylated DNA collected by tampons detects endometrial cancer.

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