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Discordant data from microarray platforms make drug research challenging.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Discordant data from microarray platforms make drug research challenging.
"Many commercial and custom-made microarray formats are routinely used for large-scale gene expression surveys. Here, we sought to determine the level of concordance between microarray platforms by analyzing breast cancer cell lines with in situ synthesized oligonucleotide arrays (Affymetrix HG-U95v2), commercial cDNA microarrays (Agilent Human 1 cDNA), and custom-made cDNA microarrays from a sequence-validated 13K cDNA library," investigators in Finland stated.
"Gene expression data from the commercial platforms showed good correlations across the experiments (r = 0.78-0.86), whereas the correlations between the custom-made and either of the two commercial platforms were lower (r = 0.62-0.76). Discrepant findings were due to clone errors on the custom-made microarrays, old annotations, or unknown causes," reported A.K. Jarvinen and colleagues, University of Helsinki, Biomedicum Biochip Center.
"Even within platforms, there can be several ways to analyze data that ...
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