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Disturbed lymphangiogenesis underlies fetal heart malformation.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Disturbed lymphangiogenesis underlies fetal heart malformation.
According to recent research published in the journal Developmental Dynamics, "ultrasound measurement of increased nuchal translucency is a method of risk assessment for heart malformations and trisomy 21 in human pregnancy. The developmental background of this nuchal edema is still not sufficiently understood. We have studied the process in trisomy 16 mice that show nuchal edema and heart malformations."
"We used trisomy 16 and wild-type (WT) embryos from embryonic day (E) 12.5 to E18.5. In WT embryos at E13, bilateral jugular lymphatic sacs are visible that share a lymphatic-venous membrane with the jugular vein. We could not in any case discern a valve between these vessels," wrote A.C.G.D. Groot and colleagues, Leiden University, Medical Center.
"At E14 in the TS16 embryos, the lymphatic sacs become enlarged showing abnormally thickened endothelium, specifically at the site of the membrane. In these embryos, severe edema develops in the nuchal region. There is a very close colocalization of the nerves with the vascular structures. The start of reorganization of the ...
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Source: HighBeam Research, Disturbed lymphangiogenesis underlies fetal heart malformation.