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VEGF is a mediator of PCB 104-induced breast cancer cell invasion.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- VEGF is a mediator of PCB 104-induced breast cancer cell invasion.
According to published research from the United States, "polychlorinated biphenyl (PCB) congeners, a group of worldwide, persistent environmental contaminants, are known to cause carcinogenesis and tumor promotion, and may also affect the development of cancer metastasis. Because vascular endothelial cells create a selective barrier to the passage of cancer cells, we hypothesize that specific PCB congeners can disrupt endothelial integrity and increase the transendothelial migration of tumor cells.
"To examine this hypothesis, we elucidated the effects of 2,2',4,6,6'-pentachlorobiphenyl (PCB 104), a representative of highly ortho-substituted non-coplanar PCB congeners, on the endothelial permeability and transendothelial migration of MDA-MB-231 breast cancer cells. Exposure of human microvascular endothelial cell I (HMEC-1) to PCB 104 induced endothelial hyperpermeability and markedly increased transendothelial migration of MDA-MB-231 cells," reported S.Y. Eum and colleagues, University of Kentucky, Medical Center.
"These effects were associated with overexpression of vascular endothelial growth factor (VEGF). PCB 104-mediated elevation of VEGF expression was induced by phosphatidylinositol 3-kinase (PI3K) but not affected by co-treatments with antioxidants or the NF-kappaB inhibitor SN50.
"In addition, the ...
- VEGF is a mediator of PCB 104-induced breast cancer cell invasion.
- Newspaper article from: Angiogenesis Weekly August 6, 2004 700+ words
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